mass transport in animals Flashcards
what is haemoglobin
a globular protein
what’s haemoglobin’s structure
curled up so hydrophilic side chains face outwards and the hydrophobic side chains face inwards
how does it’s structure make it effective
(side chains) makes haemoglobin soluble and good for transport in the blood
3 functions of HG
- associates w oxygen in the lungs
- transporting oxygen to the tissue
- dissociating w oxygen in the tissues
what is association
process in which HG binds to oxygen
what is dissociation
the process in which HG releases its oxygen
what is partial pressure
concentration of oxygen (kPa)
what is affinity
how easily the oxygen binds to the HG
how many molecules of oxygen can bind to one molecule of HG
4
Hb + 4O2 —> HbO8
haemoglobin + oxygen = ?
oxyhaemoglobin
what do HG and oxygen do in the lungs and why
associate - in lungs, partial pressure of oxygen is high so haemoglobin has high affinity for oxygen so oxygen associates
what is the partial pressure like in the lungs
high
what do HG and oxygen do in the respiring tissues
dissociate - partial pressure in tissues is low so HG has a low affinity for oxygen, the high concentration of CO2 causes the HG to change shape and dissociate
describe a dissociation curve and how the 4 oxygens associate with the HG
1 O2 - IN RESPIRING TISSUES, hard for the first O2 to associate with the iron ion (in haemoglobin) in the blood bc not quite the right shape
2+3 O2 - the association of 1st O2 causes a positive allosteric effect (change in shape) to allow 2+3 to associate easily
4 O2 - IN LUNGS, hard for 4th O2 to associate, this is bc there’s a low probability that the single O2 molecule will find an empty binding site to bind to (as 3/4 binding sites are occupied)
how does CO2 effect how HG functions
HG gives up its oxygen more readily at high partial pressure of CO2, this enables more oxygen to get to cells that are respiring at a high rate
when cells respire they produce CO2
why does HG have a high affinity for oxygen in the lungs?
at the gas exchange surface CO2 is constantly being removed. the pH is slightly raised due to the low conc of CO2, the higher pH changes the shape of the HG into one that enables it to load oxygen readily
how does decreased CO2 effect the dissociation curve
shifts it to the RIGHT - bohr effect
why does HG have a low affinity for oxygen in respiring tissues?
in tissues, CO2 is produced by respiring cells, CO2 is acidic so pH of blood is lowered. the lower pH changes the shape of HG to one with a lower affinity for oxygen. HG releases its oxygen into the respiring tissues
how does blood temperature affect dissociation?
increased blood temp reduces HG affinity for oxygen so more oxygen is delivered to the warmed up tissue