mass transport in animals Flashcards
what is the structure of a haemoglobin?
- primary structure: sequence of amino acids in the polypeptide chain.
- secondary structure: polypeptide chains are coiled into a helix.
- tertiary structure: polypeptides folded into a specific shape to carry out their function.
- quaternary structure: polypeptides linked to make a spherical molecule
what is each polypeptide associated with in a haemoglobin?
haem group: contains an Fe2+ ion.
how many oxygen molecules can an Fe2+ combine with?
1, so 4 can be carried by a single haemoglobin.
what is the loading/ associating process?
haemoglobin binding with oxygen.
happens in the lungs.
what is the unloading/ dissociating process?
haemoglobin releases oxygen.
happens at the tissues.
what is high affinity?
haemoglobin take up oxygen more easily, but release it less easily.
what is low affinity?
haemoglobin take up oxygen less easily, but release it easily.
what is the role of haemoglobin?
to transport oxygen.
how are haemoglobin adapted to transport oxygen?
- readily associate with oxygen at the surface where gas exchange takes place.
- readily dissociate with oxygen at tissues.
how does haemoglobin change its affinity?
changes its shape in the presence of certain substances.
what is the oxygen dissociation curve?
the graph of the relationship between the saturation of haemoglobin with oxygen and the partial pressure of oxygen.
how can you explain the shape of the oxygen dissociation curve?
- the first oxygen is difficult to bind to because the polypeptide subunits are closely united - gradient is shallow initially.
- binding of the first oxygen molecule changes the quaternary structure so induces subunits to bind.
- second haemoglobin needs a smaller partial pressure to bind - gradient steepens.
- after the binding of the third molecule, it gets harder again because the majority of binding sites are occupied - gradient levels off.
what does it mean if the oxygen dissociation curve is further to the left?
greater affinity of haemoglobin for oxygen.
what does it mean if the oxygen dissociation curve is further to the right?
lower affinity of haemoglobin for oxygen.
what is the effect of carbon dioxide concentration on the affinity for oxygen?
haemoglobin have less affinity for oxygen.
oxygen is released.
Bohr effect.