Mass Transport Flashcards
Why do Humans/Mammals require a Specialised Transport System?
Multicellular organisms therefore have large diffusion distances and high demand
need a transport system to deliver nutrients and remove waste from all cells
transport system in humans/mammals called Circulatory System
Circulatory System made of heart, blood vessels, blood (heart pumps blood, blood vessels carry blood, blood carries nutrients/waste)
Why is the transport system in mammals called a double circulatory system?
The heart pumps twice, the blood goes through the heart twice – generates enough pressure to supply all body cells
Why is the transport system in mammals called a closed circulatory system?
Blood is transported in blood vessels – helps to maintain pressure and redirects blood flow
Layout of Circulatory System
heart pumps blood which is carried in arteries which flow into arterioles which flow into capillaries which then are carried in venules then veins back to the heart
Artery to Arterioles to Capillaries to Venules to Veins
Artery/Arterioles carry blood away from the heart
(arterioles are small arteries)
Capillaries are the site of exchange (nutrients out, waste in)
Veins/Venules return blood back to the heart
Heart
Job is to pump blood around the body (delivers nutrients to cells and remove waste)
made of 4 muscular chambers (2 atria, 2 ventricles)
atria pumps blood to ventricles, ventricles pump blood out of heart (R to lungs, L to body)
ventricles thicker then atria (has to pump blood further)
left ventricle has a thicker muscular wall then right ventricle, therefore has stronger contractions, so can generate higher pressure and pump the blood further around the body
Blood vessels of the heart
Artery takes blood away from the heart, vein returns blood to the heart
Vena Cava supplies R atrium (with deoxygenated blood from body)
Pulmonary Vein supplies L atrium (with oxygenated blood from lungs)
R ventricle supplies Pulmonary Artery (deoxygenated blood to lungs)
L ventricle supplies Aorta (oxygenated blood to body)
Job of valves in heart
Ensure one way flow of blood, no backflow
(blood flows from atria to ventricles to arteries)
2 sets of valves: Atrio-ventricular Valve & Semi-lunar Valve
AV valve = between atria and ventricles
SL valve = between ventricles and arteries
When are AV valves open or closed?
Open = pressure in atria greater than pressure in ventricles,
Closed = pressure in ventricles greater than pressure in atria
When are SL valves open or closed?
Open = pressure in ventricles greater than pressure in arteries
Closed = pressure in arteries greater than pressure in ventricles
Describe the processes of the cardiac cycle
Filling Stage = atria relaxed, ventricles relaxed, AV valve open, SL valve closed
Atria Contracts = the SAN located in the R atrium initiates the heart beat and sends the impulse across both atria making them contract, this pushes all the remaining blood into the ventricles so it becomes full
Ventricles Contract = the AVN picks up the impulse, delays it (stops the atria and ventricles contracting at the same time, so the atria empties and the ventricles fill), sends the impulse down the septum in the Bundle of His, then at the apex the impulse goes up both walls of the ventricles in the purkine fibres, so the ventricles contract from the base upwards, pushing the blood up thru the arteries, when the ventricles start to contract the AV valve closes then the SL valve opens and blood leaves the heart
Ventricles Relax = the SL valve closes then the AV valve opens and filling starts
Formula for Cardiac Output
CO = Stroke Volume x Heart Rate
stroke volume = volume of blood pumped out of the heart in one beat
heart rate = number of beats per minuted
Cardiac Output = volume of blood pumped out of the heart in one minute
Coronary Heart Disease
high blood pressure damages lining of coronary artery
fatty deposits/cholesterol builds up beneath the lining, in the wall = Atheroma
the atheroma breaks thru the lining forming a Atheromatous Plaque on the lining, in the lumen
this causes turbulent blood flow
a blood clot (thrombus) forms
this block the coronary artery
therefore less blood flow to the heart muscle
less glucose and oxygen delivered
the heart muscle cannot respire
so it dies (myocardial infarction)
Risk Factors of CHD
Age, gender, ethnicity
Saturated fats (increases LDL, LDL deposits cholesterol in the arteries to form atheroma)
Salts (increases blood pressure – lowers water potential of the blood so it holds the water)
Smoking (nicotine = increase HR and makes platelets more sticky – blood clot, carbon monoxide = permanently blocks haemoglobin)
Obesity and Lack of Exercise
Role of Arteries/Arterioles
Generally carry oxygenated blood away from the heart
For example, Coronary Artery to the heart muscle
or Renal Artery to kidneys
exception = Pulmonary Artery carries deoxygenated blood to the lungs
Role of Veins/Venules
generally carry deoxygenated blood back to the heart
for example, Coronary Vein from heart or Renal Vein from kidneys
exception 1 = Pulmonary Vein carries oxygenated blood back to the heart
exception 2 = Hepatic Portal Vein carries deoxygenated blood from the digestive system to the liver (for filtering)
Structure of Arteries/Arterioles
Narrow lumen = maintains pressure
Lining made of epithelial cells = smooth lining to reduce friction
Thick wall = withstand pressure
Elastic tissue in the wall,
Ventricles contract – elastic tissue stretches to withstand pressure
Ventricles relax – elastic tissue recoils to maintain pressure and smooth outflow
smooth muscle in the wall (particularly in arterioles),
smooth muscle contracts – lumen narrows and arteriole constricts
smooth muscle relaxes – lumen widens and arteriole dilates
collagen in wall - prevents the artery from tearing
Structure of Veins/Venules
wide lumen = ease of blood flow
lining made of squamous epithelial cells = smooth lining to reduce friction
thin wall = vein can be squashed by skeletal muscle pushing blood back to the heart
valves in lumen = prevents backflow of blood
Function of Capillaries
Site of exchange
3 locations,
With Alveoli, takes in O2 and removes CO2
With Microvilli, takes in glucose/amino acids/monoglyceride and fatty acids/vitamins/minerals
With All Cells, deliver nutrients and remove waste
Adaptation of Capillaries
many small capillaries = large surface area
thin wall, one cell thick, squamous epithelial cells = short diffusion distance
pores between cells = allows fluid to move in and out
narrow lumen = increase diffusion time and decrease diffusion distance
Content of Blood
main component = Plasma (fluid)
plasma carries,
Cells = red blood cells, white blood cells, platelets
Solutes = nutrients, waste, protein
How does exchange occur between Capillaries & All Cells
by mass flow
fluid moves out of the blood in the capillaries carrying the nutrients
fluid moves back into blood in the capillaries carrying the waste
(fluid in the blood called plasma, fluid surrounding cells called tissue fluid, fluid in lymph system called lymph)
How is tissue fluid formed and returned to circulatory system
at the start of the capillary (arterial end) there is a build up hydrostatic pressure
this pushes fluid out of the capillary via the pores
the fluid carries the nutrients with it
the fluid surrounds the cells, this is called tissue fluid
at the finish of the capillary (venous end) the fluid moves back in by osmosis
the capillary has low water potential due to the presence of proteins (too large to move out of capillaries)
any excess tissue fluid is picked up by the lymph system and deposited in the vena cava