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pharmacodynamics > Marijuana > Flashcards

Marijuana Flashcards

1
Q

what 3 things did ancient Egyptians use cannabis for?

A
  1. glaucoma
  2. inflammation
  3. enemas
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2
Q

THC can be administered to what 4 places

A

lung, intestine, colon, skin

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3
Q

once absorbed, where does the THC concentration go?

A

extracellular water

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4
Q

once in extracellular water, what 7 routes can THC take?

A
  1. metabolism via liver
  2. biliary excretion
  3. renal excretion
  4. cannabinoid receptors at site of action
  5. hair, saliva, sweat
  6. tissue storage (fat, protein)
  7. serum protein binding lipoproteins (albumin)
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5
Q

what was the first state to outlaw cannabis?

A

Massachusetts

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6
Q

how many states have legal recreational cannabis use?

A

19

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7
Q

how many states have legal medical cannabis use?

A

15

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8
Q

what are the two receptors we have for endocannabinoids?

A

CB1 and CB2

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9
Q

what G protein are CB1 and CB2 linked with?

A

Gi (inhibitory)

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10
Q

where are CB1 receptors in high concentration? where are they low?

A

high: hippocampus, cortex, cerebellum, basal ganglia
low: brainstem and thalamus

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11
Q

CB1 receptors in the brain are in high or low levels compared to many other brain receptors?

A

high

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12
Q

where are CB2 receptors primarily located?

A

in the periphery on immune cells (has immune system functions)

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13
Q

where does CB1 inhibit memory?

A

hippocampus

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14
Q

what are two endogenous cannabinoids we produce in the body?

A

arachidonoulethanolamide (anandamide, AEA)
2-arachidonoylglycerol (2-AG)

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15
Q

CB1 receptors are prevalent at nerve terminals in both the CNS and PNS, where they function to attenuate the release of several neurotransmitters including…
Hint: there’s 7

A
  1. acetylcholine
  2. dopamine
  3. aminobutyric acid
  4. glutamate
  5. histamine
  6. norepinephrine
  7. serotonin
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16
Q

delta 9 THC is a partial ______ for CB_ receptor in the brain and is the receptor that mediates the psychotropic effects of marijuana

A

partial agonist
CB1

17
Q

what are CB1 and CB2 receptors phosphorylated by?

A

GPCR kinases

18
Q

what are the two pathways used for cannabinoids

A

internalization and the beta-arresting pathway signaling

19
Q

CB1 receptors are expressed in the ________ ____ matter of the midbrain

A

periaqueductal gray (PAG)

20
Q

CB2 receptors are expressed primarily by ______ cells

A

immune
includes lymphocytes, monocytes, macrophages

21
Q

CB2 receptors inhibit what neuron?

A

TRPV1 in dorsal root ganglia

22
Q

what are 3 therapeutic effects of cannabis (that has substantial evidence)

A
  1. treatment for chronic pain
  2. N/V from chemotherapy
  3. Improving multiple sclerosis spasticity symptoms
23
Q

there is limited evidence that cannabis is effective for….

A

increasing appetite and decreasing weight loss associated with HIV/AIDS

24
Q

the first strain approved in Florida was…

A

charlottes web

25
Q

CBD:THC strain of cannabis, charlottes web, reduced charlotte’s seizure frequency from 50 per day to _____ per week

A

2-3

26
Q

______ is the first and only FDA-approved prescription cannabidiol (CBD). it is used for _________

A

epidiolex - for epilepsy

27
Q

Rimonabant is an ______ agonist for the CB_ receptor

A

inverse agonist
CB1

28
Q

K2 or “spice” is a synthetic cannabinoid which is schedule __

A

schedule 1

29
Q

what is the feel good gene?

A

FAAH

30
Q

FAAH gene produces _________, our own natural marijuana in our brain

A

anandamide

31
Q

T or F: those with the FAAH gene mutation are less likely to become addicted to marijuana and possibly other drugs

A

true!

32
Q

those with the FAAH gene mutation have less of the enzyme ____ ______ _____ _____, which deactivates anandamide

A

fatty acid amide hydrolase

33
Q

T or F: those with the FAAH gene variant are less anxious and less inclined to like marijuana. They also have less pain

A

TRUE

pharmacodynamics (2 decks)

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