Manipulation of the immune system

Question 1

Define the MOA for H1 receptor antagonists

Answer 1

Block H1 receptors

Question 2

What are H1 receptor antagonists used for?

Answer 2

Used for allergies, conjunctivitis, reactions to insect bites

Question 3

Name some examples of antihistamines

Answer 3

Chlorpheniramine, Cetirizine, Loratadine, Fexofenadine, Promethazine

Question 4

What is the aim of anti-inflammatory drugs?

Answer 4

Reduce inflammation and swelling
Also reduce pain (by preventing inflammation)

Question 5

Define the MOA of aspirin

Answer 5

Blocking the cyclooxygenase enzyme

Question 6

Name the 2 isoforms cyclooxygenase exists in

Answer 6

COX-1 - constitutive ‘housekeeping’ enzyme - products important for normal function of stomach
COX-2 - induced - especially during inflammation - produces even more prostaglandins

Question 7

Name some commonly used NSAIDs

Answer 7

Aspirin, Ibuprofen, Naproxen, Flurbiprofen, Diclofenac sodium, Mefenamic acid, Celecoxib, Etoricoxib

Question 8

Name some side effects associated with NSAIDS

Answer 8

Gastric irritation - PGE2 is involved in inhibition of gastric acid secretion, increased gastric mucus production
Bleeding - TXA2 involved in platelet aggregation and vasoconstriction