Managing Skin Cancer Tutorial

Question 1

Which of the following is false regarding melanoma?

It can arise in the eyes
Redhair is a risk factor
Pre-existing nevi are a risk factor
Causes >75% of skin cancer deaths

Answer 1

Pre-existing nevi are not a risk factor
>50% of melanomas arise without pre-existing nevus
Atypical nevi and >100 nevi are considered a risk factor

Question 2

Which of the following is true regarding the pathogenesis of melanoma?

Answer 2

CDKN2A encodes p16, a tumour suppressor

Question 3

Which of the following statements if true?

x

Answer 3

Superficial spreading melanoma is most common variant in pale skin types

Question 4

Which of the following is true regarding melanoma detection?

Answer 4

Melanoma and basal cell carcinoma may appear grossly similar

Question 5

Which of the following investigation of melanoma is correct?

Answer 5

BRAF mutation status can inform prognosis and treatment decision

Question 6

Which of the following is true regarding keratinocyte carcinoma / dysplasia?

Answer 6

Keratinocyte carcinomas are more common in men than in women

Question 7

Which of the following is false about Basal cell carcinoma (BCC)?

Answer 7

BCC never metasises, and thus treatment is usually desirable rather than essential

Question 8

Which of the following is true regarding basal cell carcinoma management?

Answer 8

Vismodegib may be used for unresectable BCC

Question 9

Which of the following is correct regardin the cutaneous squamous cell carcinoma (SCC)?

Answer 9

May be difficult to distinguish from keratoacanthoma

Question 10

Which of the following is true regarding myocosis fungoides?

Answer 10

Any pruiritus is usually mild

Question 11

Which of the following statements if true regarding Kapsoi sarcoma?

Answer 11

It may appear as a pink patch of a polyp

Question 12

Which of the following statements is false regarding Merkel cell carcinoma?

Answer 12

Arises from cancerous merkel cells = false

MCC shares structural features with merkel cells, not derived from this

Question 13

Which of the following is not a treatment option for actinic keratoses?

Answer 13

Radiation therapy

Question 14

Which of the following represents (relative) low risk features in squamous cell carcinoma?

Answer 14

Absence of perineural invasion

Question 15

Which of the following statements is false regarding cutaneous T-cell lymphoma?

Answer 15

In mycosis fungoides, early aggressive treatment is indicated to prevent progression = false

Early aggressive therapy does not improve survival