Managing Pain and EOL Care Flashcards
Goal for Treating Acute Pain
- should not be zero pain- rather a tolerable level of pain that allows optimal physical and emotional function
- expectations should be discussed with patients and their families
- “The goal is to find the lowest effective analgesic dose as well as the amount needed before re-evaluation is necessary”
Acute Pain Treatment Options
non opiod
opiods
•ANALGESICS- NON-OPIOID
Acetaminophen (↓ production of prostaglandins)
- 4 gram/day limit (325mg, 500 mg)
NSAIDS
- COX-1
- •Ibuprofen (Motrin, Advil)
- •Naproxen (Aleve, Naprosyn)
- •Meloxicam (Mobic)
- COX-2- Celecoxib (Celebrex)
SHORT-ACTING: FOR ACUTE PAIN
- Hydrocodone - Only Combination
- Oxycodone - Alone or Combination
- Hydromorphone (Dilaudid)
- Tramadol- Alone or in Combo
- Codeine – Combination
short vs long acting opiods
SHORT-ACTING: FOR ACUTE PAIN
- Hydrocodone - Only Combination
- Oxycodone - Alone or Combination
- Hydromorphone (Dilaudid)
- Tramadol- Alone or in Combo
- Codeine – Combination
LONG-ACTING: avoid in acute pain
- Oxycodone (OxyContin)
- Morphine sulfate (MS Contin)
opiod side effects
•Somnolence - these medication can make you sleepy
•Depression of brainstem control of respiratory drive
•Urinary retention- make it hard to move your bowels’
•Nausea and vomiting - may make you sick to your stomach’
define multimodal approach
- Uses several agents or techniques, each acting at different sites of the pain pathway
- Reduces the dependence on a single medication and mechanism, and importantly, may reduce or eliminate the need for opioids
- Synergy between opioid and nonopioid medications reduces both the overall opioid dose and unwanted opioid-related side effects
Perioperative Pain Management Goals
optimal strategy??
- to relieve suffering
- achieve early mobilization after surgery
- reduce length of hospital stay
- and achieve patient satisfaction
***The optimal strategy for perioperative pain control consists of multimodal therapy to minimize the need for opioids
Opiod examples
combos
Codeine 15 to 60 mg orally every four to six hours
Oxycodone 5 to 30 mg orally every four to six hours
Hydrocodone 2.5-10 mg orally every four to six hours
Hydromorphone 2 to 4 mg orally every four to six hours
COMBOS- one or two tablets orally every four to six hours
oxycodone-acetaminophen (combinations of 300 to 325 mg acetaminophen/2.5 to 10 mg oxycodone,oxycodone-aspirin (325 mg aspirin/4.8 mg oxycodone,
hydrocodone-acetaminophen (5mg/325mg,7.5 mg/325mg,10 mg/325 mg;
acetaminophen-codeine (Tylenol No. 3, which is 300 mg acetaminophen/30 mg codeine,
*** A dose reduction of approximately ____ and a____ frequency is warranted for
- older or debilitated adults
- patients with impaired liver or kidney functioning
- low cardiac output, or respiratory compromise
*** A dose reduction of approximately 50% and a reduced frequency is warranted for
- older or debilitated adults
- patients with impaired liver or kidney functioning
- low cardiac output, or respiratory compromise
*** A dose reduction of approximately 50% and a reduced frequency is warranted for what pt populations??
older or debilitated adults
patients with impaired liver or kidney functioning
low cardiac output, or respiratory compromise
approach for radicular LBP in weekend warrior
This approach would offer:
- Cyclobenzaprine a muscle-relaxant - address the spasm
- Ibuprofen _anti-inflammator_y - ↓ inflammation of muscles
- Oxycodone an opioid analgesic -offer an analgesic effect to the current presentation
managing LBP
acute
chronic
Acute -
- 6 wk conservative tx (NSAID + activity modifiers)
- muscle relaxant - caution causes sedation
-
Glucocortioic inj - only after failure of 4-6 wk conserv therapy
- MRI is prereq
- speed short term pain but DOES NOT alter dz progression
Chronic
- same as above can include surgical intervention if all other therapy fails (not reccommended for nonspecific LBP)
- radicular sx
- neurgenic claducation from lumbar spinal stenosis
- worsening nuero deficits
- opiods as last resort
pharmacologic vs nonpharm tx for MSK pain
Nonpharm
- PT - preferred tx
- psychological approaches - pts w/ chronic pain likely have anxiety or depression and vice versa
- complementary therapy
Pharm
- Acetametophen / NSAIDs - prongly reccommended
- Muscle relaxants - risk of sedation
- opiods - typically not reccommended
- glucocorticoid inj
nonpharm tx for knee & hip osteoarthritis
PT / lifestyle modifications - FIRST LINE
- excercise to build muscle/ dec weight
Knee Brace - compliant pts
non opiod tx of knee & hip osteoarthritis
Acetametophen - mild sx
Systemic NSAID - alone or in conjugation w/ acetametophen
- INC risk of CV events
- DEC pain in degenerative joint dz
Topical NSAIDs - FIRST line in knee & hand osteoarthitis
- DEC risk of adverse effects / less systemic absorption
Glucocorticoid Injections - DEC pain w/o significant adverse events
Surgery - joint replacement if fail conserv therapy
Opiod tx of osteoarthritis
joint replacement better option
started in select cases
Signs of impending Death
- DEC blood perfusion to skin –> mottled, discolored, cyanotic skin
- DEC level of consciousness or delirium
- DEC CO & intravascular volume –> tachycardia, hypotension
- DEC urinary output –> urinary incontinence & concentrated urine
- Retention of secretions in the pharynx & upper airway ® noisy respirations (“death rattle”)
- Respirations w/ mandibular movements
- Dyspnea
- Profound weakness & fatigue
- Disorientation
- Weight loss/dehydration (third spacing)
- Swallowing difficulties
- DEC peripheral pulses
- Cheyne Stokes Respirations – noisy gurgling respirations due to secretions
Pain at end-of-life –> 3 principles (WHOS step-care approach)
list 3 types of pain
Nociceptive pain
Neuropathic
Inflammatory
type of pain that can be
Somatic or visceral.
si/sx of somatic vs visceral pain
Nociceptive pain
Somatic: Aching, throbbing, stabbing, pressure
Visceral: gnawing, cramping, sharp, stabbing – internal organs
Continuous dysesthesias, chronic lancinating or paroxysmal
described as “burning or electrical”
Tx??
Neuropathic
- Tricyclics
- SNRI
- antidepressants
tx of nocioceptive pain
NSAIDs
corticosteroids
possibly opioids
pain seen in RA, IBD.
similar to what type of pain?
Tx?
Inflammatory- released inflammatory mediators. RA, IBD.
similar to nociceptive pain in terms of character.
Tx: Anti-inflammatory
differetiate acute vs chronic pain
examples of each
Acute Pain: Lasting < 3 months and is a neurophysiological response to noxious injury that should resolve with normal healing process.
- Fx in bones, post labor pain, appendicitis
Chronic Pain: Lasting more than 3 month or beyond the expected course of an acute disease.
- Extends beyond the time of normal wound healing with the development of neurophysiological changes in CNS
- Low back pain, neck pain, chronic pancreatitis
define break through pain and how to manage
occurs when patient has pain between doses of long-acting formulations
- Hospice/ Terminal patients on average experience breakthru pain 3 times a day rating it 7 out of 10
Immediate release preparations are helpful
- Each dose should be 10-30% of the total daily dose of sustained release
- 60mg of OxyContin a day = breakthru will be 15mg q 4 hours.
Opioid Tolerance can develop, may need to rotate through other pain medications
pt experiencing break through pain:
Frequent immediate release use –> _____ in sustained release dosing.
Frequent immediate release use –> increase in sustained release dosing.
pain mgt challenges
Failure to recognize or differentiate pain from anxiety
- “pain catastrophizing” Magnification, rumination, helplessness
Lack of education to health care providers
Safety concerns, fear of patient addiction or prescription legality.
Lack of pre-existing Patient-healthcare provider relationship
Pressure to see patients rapidly
Unstable patients may not be able to verbalize/ express their pain appropriately
Stereotypes
Genetics/ Ethnicity: some groups are known to carry genetic mutations of the liver CYP450 enzyme and may metabolize some pain medications more rapidly.
describe adult nonverbal pain scale (0-2)
face
activity
guarding
physiology
respiratory
opiods MOA
Mu receptor is 7 trans-membrane G Protein coupled receptor
- Binding stabilizes the membrane so neuron can’t fire (↓ neuron transmission)
- Located in the PERIPHERY, dorsal root ganglia of spinal cord, grey matter in brainstem, midbrain and gut