Management of Specific Fractures Flashcards
What is bone?
Connective tissue that has a unique histological composition
What are the 5 functions of bone?
- Support = framework and shape of the body
- Protection = surrounds major internal organs and vasculature
- Locomotion = joints to allow flexibility and attachment site of muscles
- Haematopoesis = reservoir of stem cells forming blood cells
- Lipid and mineral storage = adipose tissue stored within bone marrow and calcium within hydroxyapatite crystals
What are 5 different types of bone?
- Flat bones - protect internal organs e.g. skull, thoracic cage, sternum, scapula
- Long bones - support and facilitate movement e.g. humerus, radius, ulna, metacarpals
- Irregular bones - vary in shape and structure e.g. vertebrae, sacrum, pelvis – pubic, ilium or ischium
- Short bones - no diaphysis, as wide as they are long, provide stability and some movemente.g. carpals, tarsals,
- Sesamoid bones - embedded within tendons, allows for dynamic action, also protects tendon from excessive stress / wear e.g. patella
What is the anatomy of the long bone?
Epiphysis = end
Metaphysis
Diaphysis = main body of the bone
What is found in the cross section of bone?
Epiphysis = cancellous (spongey) bone
In the cortex (i.e. border) = compact / cortical bone
Epiphyseal line = growth plate
Periosteum and nutrient arteries = provided blood supply and nutrients to bone
Medullary cavity
Yellow bone marrow surrounded by endosteum
What are the 2 bone ultrastructures of bone?
- Primary = woven bone:
- First type of bone to be formed in embryonic development and fracture healing
- Consists of osteoid, randomly arranged collagen fibres
- Temporary structure replaced by mature lamellar bone - Secondary = lamellar bone:
- Bone of the adult skeleton
- Highly organised sheets of mineralised osteoid, making it much stronger than woven bone
- Can be divided into compact and cancellous
What is the ultrastructure of compact (cortical) VS spongy (cancellous) bone?
Compact (cortical) bone =
- Found in the diaphysis, forms the outer part of bone
- Organised in concentric circles around a vertical Haversian canal
- Haversian canal are connected by Volkmann’s canals which contain small vessels that also supply periosteum |-|_| (so the vertical lines are haversian canals, the horizontal lines are volkmann’s canals)
- Osteocytes located between lamellae, within small cavities called lacunae - these are interconnected by a series of tunnels called canaliculi.
- Entire structure is known as an osteon, the functional unit of bone
Spongy (cancellous) bone =
- Found in the epiphysis, irregular crosslinking of trabeculae to form porous yet strong bone resistant against multidirectional lines of force
- Large spaces between trabeculae giving it a honeycombed appearance, contains red bone marrow
What are the biochemical and structural support components that make up the extracellular matrix of bone?
Mineral salts - calcium hydroxyapatite (70% of bone)
Collagen - Type I (90%) and Type V
Calcification of bone occurs when mineral salts interpose between collagen fibres, ECM is called osteoid before this
What are the cellular components of bone?
Osteobasts - synthesiseuncalcified ECM (osteoid)
Osteocytes - as osteoid mineralizes, osteoblasts are entombed between lamellae, becoming osteocytes; regulate bone mass by monitoring mineral composition and protein content
Osterclasts - they are multinucleate cells derived from monocytes and resorb bone, they release H+ ions and lysosomal enzymes
How does bone ossify (i.e. grow)?
2 methods:
- Endochondral =
Formation of bone onto a temporary cartilage scaffold e.g. hyaline cartilage replaced by osteoblasts secreting osteoid in femur = provides length - Intramembranous =
Formation of bone directly onto fibrous connective tissue e.g. temporal bone or scapula = provides width to bone
How does the blood supply between bone and cartilage differ?
Bone has very good blood supply compared to cartilage
Once bone is formed, what happens?
Constant state of turnover - remodelling
How does bone remodelling work?
Bone removal undertaken by osteoclasts = essential for body’s metabolism as removal of bone increases calcium in blood
Bone production undertaken by osteoblasts =
osteoblasts have receptors from PTH, prostaglandins, vitamin D and cytokines that activate and allow them to synthesisebone matrix
Synergistic / co-ordinated action between 2 = allow for bone remodelling
How are osteoblasts activated?
PTH
Where do osteocytes form from?
From osteoblasts, which lay down concentric lamellae and form osteons