Management of Chronic Urticaria

Question 1

Gen Stats

Answer 1

-50% of Ptnts with Urticaria –> free from lesions after 1 Year

-20% have lesions for over 20 years:
> physical urticaria are more persistent (cholinergic most common)

Question 2

Treatment

Answer 2

1) IDENTIFY + avoid precipitating factors

2) Anti-Histamines:
> Oral H1-Blockers (Hydroxyzine/Loratadine) –> contra in Chronic Urticaria (cessation usually leads to Reoccurance)

> if Uneffec: H1 + H2 Blockers (Cametidine)
or mast cell-stabilizing agents

> TCA (severe cases of Uritcaria assoc with Anxiety + dep)

3) PREDNISONE:
- used in Acute Urticaria w/ Angioedema

4) Danazol:
- long term therapy for HAE