Mammography Flashcards

1
Q

Shape Lexicon BI-RADS

A

Descriptors of the mass shape

  • Oval
  • Round
  • Irregular
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2
Q

Evaluation of an ultrasound mass

A
  • Look to the surrounding fat and not the surrounding fibroglandular tissue or generic surrounding tissue
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3
Q

Indistinct Margins

A
  • Can be related to the direct infiltration of tumor cells into the surrounding tissue
  • However, non-malignant reasons for the indistinct margins include the host inflammatory/desmoplastic response to the tumor
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4
Q

Clustered Microcysts

A
  • Mammogram appearance of microlobulated margins. Isodense without visible fat.
  • When comparing to the US think about the margins etc on the mammogram
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5
Q

Wraparound Artifact on MRI

A
  • A too small field of view will cause the overlap of the structures
  • On T1 the appropriate field of view is approximately 320mm.
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6
Q

Indistinct Margins

A
  • Indistinct margins, no clear demarcations between mass edge and surrounding tissue.
  • Can see on MR as a non-circumscribed enhancing mass
  • This is always likely an an invasive ductal carcinoma
  • Can also be invasive lobular cancers but statistically less likely.
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7
Q

Anatomic zones in the breast

A
  • Premammary
  • Mammary
  • Retromammary
  • Anterior and posterior mammary fascia surround the mammary zone.
  • Suspensory ligaments are formed by 2 leaflets of the mammary fascia
  • Anterior suspensory ligaments are Cooper’s ligaments and connect to the dermis
  • Connecting to the chest wall are the posterior ligaments
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8
Q

Calcifications on BI-RADS

A
  • BI-RADS 4 descriptors include amorphous and indistinct

- BI-RADS 5 descriptors include branching

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9
Q

Molecular Breast Imaging/ Breast Specific Gamma Imaging

A
  • Tc-99m is the radio-tracer
  • Radiation critical organ is colon. Sestamibi is excreted through the biliary system can affect the colon from the radiation more than other structures.
  • Any discrete lesion should eb onidered suspicion until proven benign by correlation with other breast imaging or biopsy
  • Negative breast gamma imaging should not prevent biopsy of the suspicious lesions on conventional imaging
  • Axillary lymph node uptake is common and benign if it corresponds to a mammographically stable node.
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10
Q

Intraductal Papilloma

A
  • US Imaging

- Isoechoic intraductal mass with internal vascular flow and adjacent fluid filled duct.

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11
Q

Ductal Carcinoma in Situ (DCIS)

A
  • Intraductal mass - less likely to present as a solid intraductal mass(compared to intraductal papilloma).
  • ## Fine, linear, branching calcifications, confirming to ducal pattern. Can push it to BI-RADS 5. Can sometimes be BI-RADS 4C.
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12
Q

Complicated Cyst

A
  • Circumscribed margins, homogenous low-level echoes, posterior enhancement,
  • Complicated because it contains internal echoes on ultrasound.
  • US guided biopsy shows cyst wall wall and proteinaceous cyst contents.
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13
Q

Margin Lexicon BI-RADS

A
  • Spiculated
  • Indistinct
  • Obscured
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14
Q

US Echogenic Halos

A
  • Likely due to unresolved spiculations causing small reflections of the ultrasound beam
  • Can also be secondary to peritumoral edema
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15
Q

Regional vs Segmental calcification distribution

A
  • Segmental - ductal distribution pattern with fine linear and branching morphology
  • Regional - distribution would not have a clear ductal arrangement. - look like shards of glass rather than branching patterns
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16
Q

US Physics

A
  • Too narrow a dynamic range on US will cause a markedly hypoechoic lesion to appear anechoic.
  • Too little gain would cause hypo echoic solid masses to be mistaken for cysts.
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17
Q

US Evaluation of Internal Mammary Lymph Nodes

A
  • Size is a better predictor of pathology than morphology.
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18
Q

Lymphatic Drainage

A
  • 75% of the lymphatic drainage of the breast is to the axillary lymph node.
  • 25% of the drainage is primarily to the ipsilateral internal mammary chain lymph nodes
  • A small amount of drainage may occur to the contralateral breast, skin, or internal mammary lymph nodes.
  • Lymphatic drainage of malignancy may occur to the contralateral axilla or subdiaphragmatic lymphatics after disruption or obstruction of the ipsilateral lymphatic by tumor or post-treatment changes,.
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19
Q

Pleomorphic Calcifications

A
  • Broken shards of glass with calcifications of varying size and shapes that are typically more dense than amorphous calcifications.
  • BI-RADS 4 regardless of the distribution of the calcifications.
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20
Q

Associated with reduced sensitivity of the breast

A
  • Very large breasts
  • > 4cm in thickness
  • Breast density does not alter sensitivity on US as it does on mammography
  • Very large breast can have hard to detect small or deep mass 2/2 mobility of the breast and the higher frequency transducers used in evaluation for breast tissue.
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21
Q

BI-RADS 3 Follow-up

A
  • Surveillance is usually performed at 6 months, 12 months, and 24 months, with option to extend to 36 months if stable at each followup
  • Amounts to a total of 3-4 Visits
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22
Q

US guided wire localization

A
  • The tip of the needle should be placed approximately 1.5-2 cm beyond (distal to) the center of the mass, which will allow the wire to be placed appropriately, with the tip of hook 2 cm from center of mass.
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23
Q

Computer Aided Detection in Screening Mammography

A
  • Sensitivity for calcifications is 86-99%
  • CAD has one helpful mark per 2000-4000 false positive marks
  • CAD is most sensitive for speculated masses
  • Low CAD recognition for developing asymmetries
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24
Q

BI-RADS 2 assessment for multiple similar circumscribed breast masses detected on screening

A
  • BI-RADS 2 is validated for multiple bilateral breast masses with mostly (>75%) circumscribed partially obscured margins on mammography when there are at least 3 total similar findings with at least 1 in each breast.
  • Not applicable with a dominant mass or suspicious features, and it excludes palpable masses.
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25
Q

Popcorn/dystrophic calcifications

A
  • BI-RADS 2(benign)
  • this finding is usually associated with a a calcified fibroadenoma or sequelae of fat necrosis
  • These are more dense than coarse heterogenous calcifications, similar to coarse/sea salt.
26
Q

Punctate Calcifications

A
  • BI-RADS 3 or 4
  • Depends on the distribution and the change over time.
  • If over multiple years on screeners prob benign (BI-RADS 3) if new with a BRCA then BI-RADS 4
27
Q

Skin Calcifications

A
  • Skin calcifications are calcifications within sebaceous glands. On occasion, atypical calcification forms may be present and a tangential magnification mammogram (after appropriate placement of a marker, i.e. “skin localization” procedure) may be necessary to confirm the cutaneous location of suspected dermal calcifications.
28
Q

Dermal calcifications vs Oil Cysts

A
  • Dermal (skin) calcifications are small, lucent centered, and often tightly grouped.
  • Oil cysts are lucent centered and may have egg shell/rim calcification but are larger and related to significant trauma/surgery.
29
Q

US Guided Biopsy Advantages

A
  • Advantages vs Stereotactic biopsy vacuum
    • Lower risk of hematoma
    • Real- time confirmation of sampling
    • Less potential for clip migration
    • Improved patient comfort
  • Disadvantages
    • Smaller sample size when compared with vacuum assisted.
30
Q

Harmonics

A
  • A significant limitation of harmonic imaging is reduced penetration. This limits its use in patient with large breasts and abundant fibrous tissue
  • Basic concept: isolating tissue with a frequency and then receiving at a multiple of that frequency.
  • Reduces artifacts also internal echoes in cysts (reverberation) and increases soft tissue contrast. Posterior features are retained.
31
Q

Sternalis Muscles

A
  • Superficial to the pectoral muscle and parallel to the sternum.
  • Can be unilateral or bilateral
  • Bilateral flame shaped densities seen on mammography
  • If worried about partially imaged mass vs muscle do a cleavage view to get better imaging.
32
Q

Appropriate indication for FNA

A
  • In general it is not appropriate to perform fine-needle aspiration of suspicious masses or calcification int eh breast because of the relatively high rate of sample inadequacy compared to core biopsy.
  • FNA are appropriate for sampling of an amenable axillary node in the setting of known or suspected ipsilateral malignancy
  • CORE is preferred if there is no ipsilateral breast abnormality associated with the abnormal lymph node.
33
Q

Galactocele

A
  • Contains inspissated milk and fat and may demonstrate a fat-fluid level on lateral mammography
  • Mammo: subtle circumscribed, mixed density, fat containing mass with lobular margins.
  • DDX: Hamartoma ; however if patient has history of breast feeding even if it has been a few years should place galactocele at the top of the list.
34
Q

Naming Schema for Mammo views

A
  • MLO - Medial (location of the tube) , lateral (location of the receptor) oblique is the angle
  • CC - Cranial (location of the tube) caudal (location of the receptor).
35
Q

Skin Localization

A
  • To localize calcifications on the skin, grid localization with BB and tangential view. Tomosynthesis can also be used to look at the level that the calcifications are at to further delineate.
36
Q

US Uses

A
  • Evaluation of palpable masses
  • Investigating a mammography abnormality
  • Investigating mass enhancement seen on MR
  • NOT USED for investigating non-mass enhancement seen on MR ( usually fibrocystic changes vs DCIS)
37
Q

Terminal Ductal Lobular Unit

A
  • Proliferation occurs in the TDLU during the postovulatory (secretory) phase of menstrual cycle
  • Occurs of the exogenous hormones
  • Pregnancy and lactation
  • Late adolescence
38
Q

MRI Phase encoding

A
  • For example if you have AP you can have too much artifact from breathing.
  • Switching right to left can diminish that artifact.
39
Q

Vertical Orientation

A
  • Vertical orientation is a worrisome feature in breast ultrasound with an increased relative risk of 4.9x compared to parallel orientation. Small masses that arise in the anterior terminal ductal lobular unit can be vertical due to its anatomic location but are usually < 1 cm in size. Malignancies can transgress fascial planes to grow in a vertical fashion, but a benign mass (e.g., fibroadenoma measuring > 1 cm) would not be expected to be vertically oriented.
40
Q

MR Imaging of Breast

A
  • performed on day 7-14 of menstrual cycle with day 1 being the start of the woman’s period.
  • Decreases background parenchymal enhancement increasing sensitivity for imaging.
  • The proliferative phase includes days 3-14 of menstrual cycle and is also known as the follicular phase. This is the ideal time for breast imaging (especially important in MR to reduce background enhancement).
  • Breast storm becomes less dense
  • Overall regression of breast epithelium
  • Lowest breast volume and water content.
41
Q

Dermal Calcifications

A
  • Most common locations are in the parasternal and inframammary folds
  • Secondary to calcium deposits in sebaceous glands
  • Benign
42
Q

Metastatic Adenopathy

A
  • metastatic nodes may lose the normal reniform shape and become round. They may have focal cortical thickening (>3mm), or they may be diffusely distended with metastatic cells and lose their fatty hila.`
43
Q

Coarse Heterogenous Calcifications causes

A

-The differential diagnoses of coarse heterogeneous calcifications include fibroadenoma/fibroadenomatoid change, stromal fibrosis, fat necrosis, ductal carcinoma in situ (usually linear or segmental distribution), and invasive ductal carcinoma.

44
Q

Pseudoangiomatous stromal hyperplasia

A

-

- Does not calcify

45
Q

Poland Syndrome

A
  • Unilateral hypoplasia or aplasia of the pectoralis muscle on MLO view
  • Ipsilateral breast hypoplasia or aplasia
46
Q

Clustered Distribution of Microcalcifications

A
  • > = 5 calcifications with <1cc of volume of breast tissue (approx 1 cm).
47
Q

Regional Distribution

A
  • Calcifications spanning > 2cm if not thought to. Conform to a duct and its branches.
48
Q

Segmental Distribution of Calcifications

A
  • Represent an introduction process involving a duct and its branches to covey a higher level of concern for possible DCIS
49
Q

Concerning Breast Aspirates

A
  • Cloudy brownish/red fluid is typical of a hemorrhagic cyst - should be sent for cytology`
50
Q

Benign Breast Aspirate

A
  • Cloudy yellow fluid
  • Green/Black fluid
  • do not need to be sent for cytology.
51
Q

Purpose of breast Lumpectomy Imagin

A
  • Cofirm the inclusion of the hookworm/seed
  • Assess the edges of the specimen for mass or calcifications
  • confirm inclusion of the lesion
  • DOESNOT ASSESS for normal margins around the tissue - that is a pathological determination
52
Q

Asymmetry

A

The term asymmetry is used in 4 distinct situations in breast imaging and may be confusing. (1) An “asymmetry” (without any modifier) is an area of fibroglandular tissue density seen on only one mammographic view. This may not be a “real” lesion and is often superimposed tissue. (2) A “focal asymmetry” is a small focal area of tissue on mammography (< 1 quadrant), lacking convex borders, conspicuity, and 3-dimensionality of a mass; it is seen on two views and may or may not be found to be a mass on diagnostic work-up. (3) A “global asymmetry” is a regional or diffuse increase in fibroglandular tissue density in one breast compared to similar area in opposite breast, ≥ 1 quadrant, and is seen in two views. (4) A “developing asymmetry” is a new or increasing focal asymmetry and has the highest positive predictive value for cancer.

53
Q

ACR Screening Guidlines

A
  • Start at age 40
  • Annual screening
  • Continue until life expectancy 5-7 yrs
54
Q

USPSTF Screening Guidlines

A
  • Biennial screening mammography for women 50 -74 yrs

- Women can choose to start at age 40 if they place a higher benefit on earlier screening

55
Q

ACS Screening Guidlines

A
  • Start at 45
  • Annual until 54 y/o
  • Biennial Screening until the life expectancy is less than 10 years.
56
Q

Indicators for Breast MR

A
  • History of Radiation to the breast at a young age.
  • Lifetime risk of cancer 20-25%
  • Dense breasts >75% - this is secondary to 5x increased cancer risk.
57
Q

MLO view drawback

A
  • Medial breast tissue can be incompletely evaluated
  • Medial breast tissue is tethered along the sternum, which can slide out of view if proper care is not taken with positioning
58
Q

Inflammatory Breast Cancer

A
  • Secondary to tumor emboli into the dermal lymphatics

- The finding on exam is peau d’orange. This is most consistent with inflammatory breast cancer.

59
Q

Developing Asymmetry Cancer Risk

A

-There are 4 types of asymmetries: asymmetry, global asymmetry, focal asymmetry, and developing asymmetry. The likelihood of underlying cancer when a developing asymmetry is identified on screening mammography is ~15%. When identified on diagnostic mammography (due to symptoms, short interval follow up of a BI-RADS 3 lesion etc), it is about 25%.

60
Q

Stereotactic Pair Imaging

A

-Stereo pairs are obtained at 30 degrees from each other (15 degrees to each side of the scout image).

61
Q

Fibroadenoma on US

A
  • A well marginated hypoechoic oval, wider than tall mass is most likely to be a complicated cyst or a fibroadenoma.
  • When working with younger patients this finding is likely more indicative of a FA.
62
Q

Lipoma

A

-On US, there is a circumscribed, oval shaped, mass that is iso-echoic to slightly hyperechoic to the surrounding subcutaneous fat.