Maloney et al. (2014)

Question 1

Pharmaceutical interventions in autism

Answer 1

FDA approved for autism treatment of irritability
Risperdone
Aripriprazole
Pros and cons to risperdone?

Question 2

Aripriprazole mechanisms of action
Partial serotonin and dopamine agonist
D2 and 5-HT1A receptors
5-HT2A antagonist; moderate H1 affinity- avoids some side effects

Answer 2

Aripriprazole mechanisms of action
Partial serotonin and dopamine agonist
D2 and 5-HT1A receptors
5-HT2A antagonist; moderate H1 affinity- avoids some side effects

Question 3

Study purpose?
Participants?
Materials?
Procedure?
Results?
Discussion?

Answer 3

• Irritability decreased in the majority of participants.
• Average weight gain was 3 pounds in 8 weeks.
• All chose to continue use the drug after the study.
• We report here on 14 children and adolescents, 8 of whom were males (age 13 – 1.3 years) and 4 of whom were females (age 12 – 2.3 years).