Malnutrition + Overnutrition Flashcards

1
Q

what are the 4 disease related caused of malnutrition?

A

decreased intake
impaired digestion/absorption
increased nutritional requirements
increased nutrient losses

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2
Q

what common symptoms of disease cause increased nutrient losses?

A

vomiting and diarrhoea

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3
Q

what are the 9 main psychosocial causes of malnutrition?

A
inapproptiate food provision
lack of assistance
poor eating environment
lack of cooking skills/facilities
self neglect
bereavement
inability to access food
deprivation
loneliness
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4
Q

what are the 9 major adverse effects of malnutrition?

A
impaired immune responses
impaired wound healing
reduced muscle strength and fatigue
cardio-resoiratory weakness
immobility
water and electrolyte disturbances
impaired thermoregulation
menstrual irregularities
psycho-social effects
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5
Q

weight loss is a symptoms for what major 8 GI diseases?

A
coeliacs diseasse
crohns disease
colorectal cancer
gastric cancer
oesophageal cancer
intra abdominal infection
impaired GI motility
acute liver disease
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6
Q

what is the aim of the MUST score?

A

a screening tool to identify adults who are malnourished or at risk of malnourisment

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7
Q

when must patients be nutritonally screened using MUST?

A

within 1 day of admission

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8
Q

what is Step 1 of MUST?

A

BMI score
above 20 = 0
18.5-20 = 1
below 18. 5 = 2

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9
Q

what is Step 2 of MUST?

A
weight loss score
(unexplained weight loss in past 3-6 months)
less than 5 percent = 0
5- 10 percent = 1
greater than 10 percent = 2
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10
Q

what is Step 3 of MUST?

A

if patient is acutely ill AND likely to be no nutritional intake for >5days = 2 points

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11
Q

what is Step 4?

A

add scores from step 1, 2 and 3 to calculate overall risk of malnutrition
0 = low risk
1 = medium risk
2+ = high risk

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12
Q

how do you calculate BMI?

A

mass (kg)/

height^2(m)

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13
Q

what is the 4 step pyramid of nutritional support?

A

food
oral nutritional supplements
enteral nutrition
parenteral nutrition

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14
Q

what is refeeding syndrome?

A

occurs when previously malnourished are fed with high carbohydate loads
this causes a rapid decline in electrolytes and an increase in extracellular volume which results in organ dysfunction

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15
Q

why is there an increase in extracellular volume (oedema) in patients with refeeding syndrome?

A

due to salt and water retentsion

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16
Q

what are the main metabolic features of refeeding syndrome?

A
hypokalaemia
hypophosphataemia
hypomagnesaemia
altered glucose metabolism
fluid overload
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17
Q

what are the physiological features of refeeding syndrome?

A
arrhythmias
altered level of consciousness
seizures
respiratory failure
cardiovascular collapse
death
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18
Q

how do you prevent refeeding syndrome in moderate risk patients?

A

introduce nutritional support at a maximum of 50% of requirements for first 8 hours, increase nutritional support after 48 hours if monitoring reveals no problems

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19
Q

what must you do to prevent refeeding syndrome in high risk patients?

A

rehydrate carefully and supplement potassium, magnesium, phosphate, calcium, thiamine and vit B
start feeding at 5-10kcal/kg/day

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20
Q

what are the BMI categories?

A
below 18.5 = underweight
18.5- 24.9 = normal
25- 29.9 = overweight
30- 39.9 = obese
40+ = morbidly obese
21
Q

what are the 9 main consequences of obesity?

A
diabetes
heart disease
NAFLD
repiratory disease
stroke
osteoarthriris
some cancers (uterus, breast, prostate, colon)
gallbladder disease
dementia
22
Q

what s the effect that long-term obesity has on brain-reprogramming?

A

brain becomes to view extra weight as normal and dieting as a threat to body survival
(so defends new weight by switching on compensatory mechanisms to maintain energy expenditure)

23
Q

what part of the hypothalamus seems to be associated with decreased energy expenditure?
(ie causes obesity)

A

lateral hypothalamus

24
Q

what part of the hypothalamus seems to be associated with increased energy expenditure?
(ie causes leaness)

A

ventromedial hypothalamus

25
what are the 3 basic concepts which underlie the control of energy intake and body weight?
1. satiety signalling (short term) 2. adiposity negative feedback signalling (long term) 3. food reward
26
what is satiation?
sensation of fullness generated during a meal
27
what is satiety?
period of time between termination of one meal and the initiation of the next
28
what type of feedback occurs when satiation signals increase during meal to limit meal size?
negative feedback
29
what are 5 gut satiation signals?
``` cholecystokinin (CCK) peptide YY (PYY) glucagon-like peptide (GLP-1) oxyntomodulin (OXM) obestatin ```
30
what is ghrelin?
a gut hunger signal secreted from oxyntic cells in stomach
31
when do levels of ghrelin increase?
before meals
32
when are levels of ghrelin raised?
fasting | hypoglycaemia
33
what 2 hormones report fat status to the brain?
leptin | insulin
34
where is leptin made and released from?
fat cells
35
where is insulin made and released from?
b-cells in pancreas
36
what happens to the levels of leptin and insulin as fat storage increases?
hormone levels in the blood increase
37
what is the response of the brain to increased insulin and leptin?
eat less and increase energy burn
38
in the obese state what happens to leptin and insulin control mechanisms for reporting fat status?
they malfunction
39
how are peripheral actions different to central actions of insulin?
insulin peripherally cause build up of fat/glycogen etc (anabolic) insulin in the brain causes break down of fat (catabolic)
40
why doesnt the high levels of leptin (that accompany high levels of fat storage) in obese people cause catbolism of fat?
severe leptin resistance present in most ovese individuals
41
what is the main drug for treatment of obesity?
orlistat
42
what is the function of orlistat?
inhibits pancreatic lipase to decrease lipid absorption
43
what are the side effects of orlistat?
cramping severe diarrhoea vitamin deficiency (need to take vitamin supplements)
44
why isn't orlistat efective over long term?
rebound weight
45
what is liraglutide?
a glucagon-like-peptide 1 receptor agonist
46
compare dosing of liraglutide for type 2 diabetes to dosing for weight loss?
higher doses used for weight loss than diabetes
47
how is liraglutide administered?
injections
48
what is the most effect therapy for obesity?
bariatric surgery