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Cancer Predispositions > Malignant Morphology > Flashcards

Malignant Morphology Flashcards

1
Q

Hematopoietic Marker

A

CD45

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2
Q

Immature Markers

A

HLA-DR (MHC-II)
CD34
TdT (lymphoid)
CD117 (myeloid)

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3
Q

B-cell Markers

A

CD19
CD20
CD22
CD79a
CD10 (common lymphoid marker)
kappa/lambda light chain
sIg or cIg

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4
Q

T-cell Markers

A

CD1a (immature)
CD2
CD3
CD4
CD5
CD7
CD8
CD99 (immature)

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5
Q

NK cell Markers

A

CD16
CD56

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6
Q

Myeloid Markers

A

CD13
CD14 (monocytic)
CD15
CD33
CD 64/65 (Monocytic)
MPO (lineage defining)
Lysozyme

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7
Q

Hyperdiploid B-ALL

A

51-66 chromosome
DNA index >1.16
Gains of chromosomes 4, 10, 17
Most common cytogenetic abnormality of BALL
Good prognosis

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8
Q

Tel-AML

A

ETV6-RUNX1
t(12;21) - cryptic translocation, needs FISH
Most common translocation in BALL
Good prognosis

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9
Q

t(5;14)

A

IL3-IGH
Profound Eosinophilia
Morphologically distinct BALL

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10
Q

t(1;19)

A

TCF3-PBX1
(E2A-PBX1)

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11
Q

DS ALL

A

Normal cytogenetics
Cryptic CRLF2 translocations but wo poor px

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12
Q

MLL ALL

A

KMT2A
Most common ALL cytogenetics in infants
11q23
BAD prognosis

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13
Q

Philadelphia ALL

A

BCR-ABL 9q22
p190
bad prognosis

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14
Q

Ph-like ALL

A

TKI (EPOR, CRLF2)
IgH
JAK2/3 abberations
IKZF1 deletions - Ikaros (v. bad)
Poor prognosis

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15
Q

t(17;19)

A

TCF3-HLF
hypercalcemia
coagulopathy
bad prognosis

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16
Q

Low hypodiploid ALL

A

32-39 chromosomes
assoc with TP53
very poor prognosis

17
Q

Near haploid ALL

A

24-31 chromosomes
can masquarade as hyperdiploid, need FISH
results in >4 copies of RUNX1 w/o multiple copies of chromosome 21
bad prognosis

18
Q

Burkitt Leukemia/Lymphoma

A

deeply basophilic vacuolated cytoplasm
CD45 bright, B-cell markers, surface Ig, negative for TdT and CD34
MYC rearrangements
8;14 MYC;IgH
2;8 MYC; IgK
8;22 MYC;IgL

19
Q

T Lymphoblastic Leukemia/Lymphoma

A

TCR rearrangements partnered with HOX genes
TAL1 transloacations 1p32
Deletion of 9P
Co-express myeloid markers

20
Q

Early T Precursor Leukemia

A

CD1a-, CD10-, CD8-, positive for stem cell markers: CD117, CD34, HLA-DR, CD13, CD33, CD11b

21
Q

APML

A

t(15;17)
PML-RARA
Hypergranular variant
HLA-DR-, CD34-
CD117+, CD64+
Intensely MPO+
Microgranular variant
HLA-DR+, CD34+, CD2+

22
Q

Core Binding Factor AML

A

Inv16 CBFB-MYH11 FISH
Eosinophilic, dysplasia
t(8;21) RUNX1:RUNX1T1 CBFA
salmon pink granules with long slender auer rods
Defined by cytogenetics not blast count
Good prognosis

23
Q

MLL ALL

A

KMT2A t(4;11)
Infants
CD10- with myeloid markers

24
Q

MLL AML

A

MPO- CD14+ CD64+ CD 65+ (monocytic)
Infants often extramedullary chloromas
Many translocations of 11
Biphenotypic and therapy related AML

25
Q

TAM

A

HLA-DR- CD41+ CD61+ CD4+ CD7+
Big Blue Blebby blasts
GATA1
Resolves <6 mo or evolves to AML
Fibrosis

26
Q

JMML

A

Hgb F increased, monocytosis
PTPN11 somatic mutation (KRAS, NRAS)
NF1
GMCSF hypersensitivity

27
Q

Hepatosplenic gamma/delta T-cell Lymphoma

A

Isochromosome 7q
sporadic in teenage males, otherwise immunosuppression is cause

28
Q

HLH

A

Decreased NK cell function
Assoc with T-cell lymphoma
HSCT for familial

29
Q

GATA2

A

N371K germline
Multilineage dysplasia

30
Q

Germline predispositions to MDS/AML

A

Just AML: CEBPA, DDX41
w/plt disorder: RUNX1, ETV6, ANKRD26
Other: GATA2, BMfx, telemoere dysfx, NF1, Noonan, down syndrome

31
Q

CML

A

Neutrophilia w left shift
Basophilia, eosinophilia
thrombocytosis (acquired VWD)
BCR-ABL p210

32
Q

Polycythemia Vera

A

JAK2 V617F

33
Q

Essential Thrombocytosis

A

JAK2 V617F, MPL, CALR

Cancer Predispositions (4 decks)

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