Malignant Mesenchymal Neoplasla Flashcards
What do Fibrosarcoma masses look like in a gross section?
A: Fish-flesh masses that are rarely encapsulated.
: Describe the histopathological features of Fibrosarcoma.
Pattern
It consists of broad interlacing bands of fibroblasts with streaming or herringbone منظر شوك السمك
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How does well-differentiated Fibrosarcoma differ from poorly
Well differentiated: more collagen, less dysplasia. Poorly differentiated: less collagen, highly cellular, more mitosis and more pleomorphism.
What is the definition of Fibrosarcoma?
is a malignant tumor of fibrous tissue.
What is the definition of Malignant Fibrous Histiocytoma
It is a malignant tumor of fibrous tissue & histiocytes (biphasic tumors)
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Malignant Fibrous
histiocytoma
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is the most common soft tissue sarcoma in adults.
Name the histological subtypes of Malignant Fibrous Histiocytoma.
1-Storiform Pleomorphic
, 2-Myxoid,
3-Giant cell,
4-Angiomatoid.
Describe the histopathological features of the Storiform Pleomorphic subtype of Malignant Fibrous Histiocytoma.
It is the most common subtype. It consists of short fascicles of spindle cells in storiform pattern
What is the name of the malignant tumor of adipose tissue?
Liposarcoma
What is the second most common soft tissue sarcoma after malignant fibrous histiocytoma
Liposarcoma
What is the incidence of Liposarcoma in the head and neck region?
Rare in head & neck region.
What are some common sites for Liposarcoma in the head and neck?
Neck, cheek, tongue
Describe the gross section appearance of Liposarcoma.
Macroscopic
Encapsulated, invasive and pale gray neoplasm (fish-flesh appearance & yellowish fatty areas in less differentiated
Name the histological types of Liposarcoma
1-Well differentiated,
2- Myxoid,
3- Round cell,
4- Pleomorphic,
5- Dedifferentiated.
Describe the Well Differentiated type of Liposarcoma histologically.
Resemble benign lipoma but demonstrating scattered lipoblast with atypical hyperchromatic nuclei
Describe the Dedifferentiated type of Liposarcoma.
: Combination of well differentiated & poorly differentiated.
Describe the Myxoid type of Liposarcoma histologically
is the most common type.
Proliferating lipoblasts within myxoid stroma that contain a rich capillary network
Describe the Round Cell type of Liposarcoma
More aggressive form, l
Describe the Pleomorphic type of Liposarcoma.
bizarre giant cells.
What is Kaposi’s sarcoma?
A: Unusual vascular tumor.
Name the types of Kaposi’s sarcoma
1- Classic,
2- Endemic (African),
3- Iatrogenic immunosuppression associated,
4- AIDS-related.
Q: What are the characteristics of Classic (chronic) type Kaposi’s sarcoma regarding age, sex, and site?
A: Age: late life. Sex: 90% males mostly Italian, Jewish and Slavic ancestry. Site: skin (lower extremities) with late visceral involvement rar in oral
How many subtypes is the Endemic type of Kaposi’s sarcoma in Africa divided into
a) Benign nodular: classic type but in young age (25-40)
B)Aggressive infiltrative type: locally invasive l
C) Florid form of K.S. rapidly progressive &aggressive lesions
D)unique lymphadenopathic type: young black African
children
What is immuno-suppression associated Kaposi’s sarcoma linked to
immunosuppressed patients in organ transplantation due to decreased cellular immunity
