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Tri 6 - Tumors > Malignant (Ewing's and on) > Flashcards

Malignant (Ewing's and on) Flashcards

1
Q

Primitive primary malignant tumor of bone derived from connective tissue framework of bone marrow

A

Ewing’s Sarcoma

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2
Q

Ewing’s Sarcoma age range

A

10-25 yo peak at 15 years

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3
Q

Localized pain with swelling usually palpable soft tissue mass

A

Ewing’s Sarcoma

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4
Q

Only primary malignant bone tumor that

simulates an infection

A

Ewing’s Sarcoma

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5
Q

Fever, Anemia, Leukocytosis, and Elevated ESR

A

Ewing’s Sarcoma

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6
Q
  • Permeative
  • Wide zone of transition
  • Laminated periosteal reaction (or spiculated)
  • Codman’s Triangles
  • Cortical saucerization is early sign
  • Usually mixed lytic and sclerotic patterns
A

Ewing’s Sarcoma

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7
Q

early sign of Ewing’s sarcoma

A

Cortical saucerization

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8
Q

Cortical saucerization is due to

A

subperiosteal extension of tumor through

Haversion systems of cortex

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9
Q

MC primary malignant bone tumor to metastasize to bone

A

Ewing’s Sarcoma

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10
Q

Laminated periosteal

reaction seen in

A

Ewing’s

Sarcoma

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11
Q

Produces varying amounts of collagen

in 30-50 yo and presents with Local pain and swelling that may refer pain to joint

A

Fibrosarcoma

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12
Q

1/3 of fibrosarcoma patients present with

A

pathologic fracture

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13
Q

Malignant Fibrous Histiocytoma (MFH)

aka

A

Undifferentiated Pleomorphic Osteosarcoma

UPS

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14
Q

Fibrosarcomas are purely _______, with no _______

A

radiolucent, calcification

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15
Q
  • Highly destructive lesion
  • Expansile
  • Medullary in origin
  • Permeative, metaphyseal
  • Eccentric
  • Endosteal scalloping
A

Fibrosarcoma

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16
Q

A secondary Fibrosarcoma

may be caused by

A

Paget’s disease

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17
Q

Fibrosarcoma

usually metastasize to

A

lung and liver

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18
Q

Rare primary malignant bone tumor arising from
vestigial remnants of notochord, which have
persisted in the nucleus pulposus of the IVD

A

chordoma

19
Q

m/c location for chordoma

A

Sacrococcygeal chordoma (50%)

20
Q

chordoma can cross the

A

disc

21
Q

Sacrococcygeal Chordoma will present with

A

constipation

22
Q 
– Increased intracranial pressure, and encroachment
on adjacent structures
– chronic Headache 
– Blurred vision, diplopia
– Nasal obstruction
– Cerebellar involvement
A

Spheno-Occipital Chordoma

23
Q

vertebral cordomas mc affect the __ vertebral body and spares the

A

C2, posterior elements

24
Q

Presents as localized bone lesion with Dull aching pain, not relieved by rest
but Patient feels fairly good overall

A

Non-Hodgkin’s Lymphoma

aka Reticulum Cell Sarcoma

25
Q

Non-Hodgkin’s Lymphoma Tumor begins in

A

medullary bone

26
Q

Laminated periosteal reaction and Pathological fracture is common (initial complaint)

A

Non-Hodgkin’s Lymphoma

27
Q

radiograph of 51-year-old man with left leg pain demonstrates a
lytic lesion with a moth-eaten appearance centered in the mid
diaphysis of the tibia

A

Non-Hodgkin’s Lymphoma

28
Q

usually more symptomatic than blastic lesions

A

Lytic lesions

29
Q

Primary site of skeletal involvement for Hodgkin’s Lymphoma of Bone

A

vertebral body

30
Q

Hodgkin’s Lymphoma of Bone is also common in

A

lower thoracic and upper lumbar spine

31
Q

10-20% of patients with Hodgkin’s lymphoma

develop

A

skeletal disease

75% Osteolytic

32
Q

accounts for
approximately 3% of malignant bone neoplasms and comprises less than 5% of all extranodal
non-Hodgkin’s lymphomas

A

Primary lymphoma of the bone

33
Q

initial involvement of a single bone (long) with no evidence of
disease elsewhere for at least 6 months

A

primary bone lymphoma

34
Q

characterized as “mottled” or “moth-eaten” radiolucencies,

corresponding to regions of marrow and cortical replacement by lymphoma cells

A

primary lymphomas of bone

35
Q

reported in about

60% of Primary Lymphoma of Bone cases

A

Periosteal reaction

36
Q

Primary Lymphoma of Bone enhances with

A

gadolinium contrast

37
Q

Primary Lymphoma of Bone patients generally present with

A

localized bone pain

and, less frequently, soft-tissue swelling

38
Q

Pain of an intermittent, aching nature, with localized swelling and tenderness in a 20-40 yo

A

Giant Cell Tumor

39
Q

begins in the metaphysis and extends to end of long bone to the subarticular region

A

Giant Cell Tumors

40
Q

mc spinal site for a giant cell tumor

A

Sacrum

41
Q

Quasimalignant tumor of bone

A

Giant Cell Tumors

42
Q
  • Eccentric
  • Metaphyseal
  • Purely lytic (60%)
  • Extends to subarticular region of bone
  • Thinned, expanded cortex
  • Soap bubble
A

Giant Cell Tumor

43
Q

definitive diagnosis of a Giant Cell Tumor must be correlated by three means:

A

Radiologic, Clinical and Histologic

Tri 6 - Tumors (12 decks)

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