Malignancy Associated Hypercalcaemia

Question 1

Causes

Answer 1

PTH related protein (SCC), osteolysis, myeloma.

Really poor prognosis, 75% mortality

Question 2

Signs/Symptoms

Answer 2

Weight loss, polydipsia/uria, Constipation, weakness, confusion, dehydration, siezures.

Question 3

Management

Answer 3

Aggressive rehydration.
Bisphonphonates (allendronic acid, zoledronic) if eGFR below 30.
Can give calcitonin with results within 2 hours but tollerance.