Male Reproductive System - Summary

Question 1

Seminiferous tubules have ______ ____ + ________ _____

Answer 1

Seminiferous tubules have sertoli cells + developing sperm

Question 2

Sertoli cells = supporting function - provide _______________ ___ _____ __________

Answer 2

Sertoli cells = supporting function - provide microenvironment for sperm development

Question 3

tight junctions between sertoli cells = ______ _______ _______

Answer 3

tight junctions between sertoli cells = blood testis barrier

Question 4

sertoli cells = exocrine function _________ _____ + ________ _________ _______

Answer 4

sertoli cells = exocrine function producing fluid + androgen binding protein

Question 5

endocrine function producing ________ ________ _________ + inhibin

Answer 5

endocrine function producing müllerian inhibiting subtance + inhibin

Question 6

sertoli cells express ________ ________ + FSH _______

Answer 6

sertoli cells express androgen receptors + FSH receptors

Question 7

spermatogenesis dependant on ___ + high __________ ___________ however completely dependant on sertoli cells for _________

Answer 7

spermatogenesis dependant on FSH + high testicular testosterone however completely dependant on sertoli cells for development

Question 8

Leydig cells in peritubular compartment - express __ ________, produce testosterone + _____amounts of DHT+Estradiol-___

Answer 8

Leydig cells in peritubular compartment - express LH receptor, produce testosterone + small amounts of DHT+Estradiol-17B

Question 9

Testosterone converted to ___ and _________-___: regulate _________ sex characteristics required for development, ______ + function of male reproduction tract

Answer 9

Testosterone converted to DHT and Estradiol-17ß: regulate secondary sex characteristics required for development, growth + function of male reproduction tract

Question 10

estrogen is required for ____ ___________ + modulation of LDL, VLDL and ___

Answer 10

estrogen is required for bone mineralisation + modulation of LDL, VLDL and HDL

Question 11

endrocrine function regulated in __________-_______-______ axis

GnRH in hypothalamus stimulates __ + FSH in _______

Answer 11

endrocrine function regulated in hypothalamus-pituitary-testis axis

GnRH in hypothalamus stimulates Luteinising Hormone + FSH in pituitary

Question 12

circulating _________, ___ and estradiol exert negative feedback in pituitary and hypothalamus

Answer 12

circulating testosterone, DHT and estradiol exert negative feedback in pituitary and hypothalamus

Question 13

male reproductive tract includes _________ and vas deferens and a_______ g_____ the seminal vesicles + prostate gland

Answer 13

male reproductive tract includes epididymus and vas deferens and accessory gland the seminal vesicles + prostate gland

Question 14

secrertions produce most of the semen which provide bulk to sperm, provide nutrients to sperm, prevent spermcapacitation and inhibit sperm motility

Answer 14

secrertions produce most of the semen which provide bulk to sperm, provide nutrients to sperm, prevent spermcapacitation and inhibit sperm motility

Question 15

emission (emptying contents from vas deferens to prostatic urethra ) + ejaculation happen through primarily sympathetic simulation of musculans + somatic simulation of pelvic muscles

Answer 15

emission (emptying contents from vas deferens to prostatic urethra ) + ejaculation happen through primarily sympathetic simulation of musculans + somatic simulation of pelvic muscles

Question 16

What is the role of Leydig cells?

Answer 16

Testosterone - essential for the maintenance of spermatogenesis

Question 17

How long is the process of spermatogenesis?

Answer 17

72 days - cohort entering process every 16 days

Question 18

How many spermatogenic stages are there?

Answer 18

6

Question 19

Which cells express the androgen receptor?

Answer 19

sertoli cells - not germ cells

Question 20

What is the blood testis barrier composed of?

Answer 20

specialised junctions between sertoli cells - including tight junctions and gap junctions

Question 21

How do sperm get the glucose they require for meiosis?

Answer 21

via the GLUT1 transporter → converted to lactate

Question 22

What converts Leydig cells derived testosterone to estradiol-17ß and where is it produced?

Answer 22

aromatase (CY19) by sertoli cells

Question 23

Which protein hormone related to transferring growth factor Beta (TGFß) keeps FSH levels within a pecific range?

Answer 23

inhibin