Male Reproductive Drugs

Question 1

Drugs Acting on Male Reproductive System

Answer 1

Use:
* hormone replacement therapy
* Muscle mass
* Sexual function

Question 2

Androgens

Answer 2

• Acts like male hormone testosterone - ( Used to effect male reproductive system including male steroidal hormones or androgens)
• Replacement therapy for hypogonadism
• Treat certain breast cancers

hypogandism is underdevloped testes

Question 3

Types of Androgens

Answer 3

• ** Danazol (Danacrine)**- synthetic used to block rlease of FSH and LH in women
  Treatment for endometriosis
• **Testoloctone **
• **Testosterone ** -

Question 4

Therapeutic Action

Answer 4

• Form of testosterone responsible for growth and development of male sex organs and secondary sex characteristics
• Act to increase retention of nitrogen, sodium, pottasium and phophorus
• Decrease in urinary excretion of calcium- androgen is thus used to treat osteoporosis in combination with estrogen

Question 5

Nursing Implementation

Answer 5

• Remove old dermal system before applying new system to clean dry intact skin - ensure accurate administration and decrease risk of toxic level
• monitor liver function periodicaly with long term therapy
• discontinue use if signs of hepatic dysfunction (elevated liver enzymes, trouble with bloodclotting, heavy periods, bleeding from gum)
• Provide thorough pt teaching

Question 6

Pharmacokinetics

Answer 6

• Well absorbed and widely distributed throughout the body
• metabolized in liver; excreted in urine
• Route- IM
• Onset- Slow
• Peak - 1 to 3 days
• Can also be given dermally
• Onset- rapid
• Peak- 24hrs

Question 7

Contraindications & Cautions

Answer 7

• Contraindicated in pregnancy and lactation (adverse effects on fetus and neonate)
• Allergy to drug or ingredient of drug
• Presence of prostate or breast cancer in men
• Caution- liver dysfunction or cardiovascular disease, can be exacerbated by effects of the hormone

If androgens are to be used another method should be used while feeding

Question 8

Adverse Effect

Answer 8

• headache
• dizziness
• acne
• edema
• nausea
• hepatocellular carcinoma
• hirsutism
• hypoestrogenic effects (flushing, sweating, vaginitis)
  *androgenic effects such as acne, deepening voice, oily skin

hirsutism is increased hair distribution

Question 9

Drug to Drug Action

Answer 9

• decreased thyroid function (effects can last up to 2 weeks after discontinuation of androgen therapy)