Male Hypogonadism

Question 1

Define hypogonadism

Answer 1

Not enough production of testosterone or sperm

Question 2

Primary Hypogonadism

Answer 2

Primary: Genetic diseaeses: Klinefelter, Y-chromosome microdeletions, cryptorchidims

OR

Acuired: infectious (mumps, echovirus), radiation, meds, trauma, alcohol

Question 3

Secondary Hypogonadism

Answer 3

Kallman syndrome, Prader-Willi, stress, malnutrition, excess exercise, hyperprolactinemia, chronic opioid use

Question 4

Confirm diagnosis of hypogonadism

Answer 4

Low serum testosterone checked in AM and repeated on 2 occasions.

Question 5

Total serum testosterone

Answer 5

Include SHBG, albumin and free testosterone.

Bioavailable testosterone includes testosterone loosely bound to albumin and free testosterone.

Question 6

Treatment of hypogonadism

Answer 6

estosterone replacement therapy can be initiated to maintain secondary sexual characteristics, sexual function, and quality of life.

Question 7

What to check before starting testosterone therapy

Answer 7

digital rectal examination and sleep apnea test, PSA, hematocrit

Question 8

Testosterone therapy inhibits ______.

Answer 8

Spermatogenesis