Male GU pharm Flashcards
1
Q
BPH tx, a1 antagonists
A
terazosin doxazosin tamsulosin silodosin alfuzosin prostate has a1A receptors PROMP relief
2
Q
terazosin
A
a1 specific
not uroselective
can cause postural hypotension
drug interactions with PDE-5 inhibitors
3
Q
doxazosin
A
a1 specific
not uroselctive
postural hypotension
interacts with PDE-5 inhibitors
4
Q
tamsulosin, silodosin
A
a1A= a1D uroselective reduced ejaculation, IFIS interacts with PDE5 inhibitors CYP inhibitor
5
Q
alfuzosin
A
non-specific a1 selective uroselective, distributes to prostate > serum QT prolongation CYP inhibitor PDE5 interactions
6
Q
5a reductase inhibitors
A
finasteride (SAR2 specific, which is the prominent SAR in prostate) dutasteride (SAR1 and 2) delayed action shrinks prostate relief takes 3-6 months
7
Q
finasteride and dutasteride side effects
A
erectile dysfunction gynecomastia depressed libido ejactulation disturbances no significant drug interactions
8
Q
tadalafil
A
treats BPH and erectile dysfunction
PDE5 inhibitor
don’t use with a1 blockers
9
Q
Sildenafil
A
viagra DOA 4 hrs empty stomach hepatic clearance blurred or blue vision at high dose
10
Q
vardenafil
A
levitra DOA 4-5 hr empty stomach hepatic CYP3A4 clearance blurred or blue vision at high dose needs to be hemodynamically stable
11
Q
tadalafil
A
Cialis DOA 36 hrs stomach contents dont matter hepatic CYP3A4 clearance back pain, myalgia, limb pain don't use with a1 blockers
12
Q
avanafil
A
stendra take 15 min prior DOA 4 hr stomach contents dont matter hepatic CPY3A4 clearance blurred or blue vision side effect at high dose
13
Q
alprostadil
A
prostaglandin E1
increases cAMP and decreased Ca
injection
can cause priapism (medical emergency)
14
Q
priapism tx
A
phenylephrine +aspirin
