Male GU Disorders Flashcards

1
Q

Pain in GU disorders

A

o Can be severe

- Urinary tract obstruction (kidney stones)
- Inflammation 

o most severe when it involves the parenchyma of a GU organ

- Pyelonephritis
- Prostatitis
- Epididymitis

o Inflammation of the mucosa of a hollow viscous usually produces discomfort

- Cystitis
- Urethritis

o Tumors - No pain unless :

- Obstruction 
- Extend beyond the primary organ to involve adjacent nerves 

- Gastrointestinal symptoms 
- Nausea
- Vomiting
- Ileus
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2
Q

Renal pain

A

o Ipsilateral costovertebral angle just lateral to the sacrospinalis muscle and beneath 12th rib
o Acute distention of the renal capsule
o Renal pain may also be confused with pain resulting from irritation of the costal nerves, most commonly T10-T12
-Not colicky in nature
-Severity of radicular pain may be altered by changing position

o Pyelo is usually diffuse pain
o Colicky is usually sharp pain

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3
Q

uretheral pain

A

o Usually acute and secondary to obstruction

- Midureter (Rt side) referred to the right lower quadrant (McBurney's point)  and simulate appendicitis
- Midureter (Lt side) referred over the left lower quadrant and resembles diverticulitis. 
- Scrotum in the male or the labium in the female.
- Lower ureteral obstruction frequently produces symptoms of bladder irritability (frequency, urgency, and suprapubic discomfort)

o Sometimes right kidney stones can mimic an appendicitis
o Kidney stones have a colicky waxing and waning quality to them

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4
Q

vesical (bladder) pain

A

o Vesical pain is due to

- Overdistention 
- Inflammation
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5
Q

prostatic pain

A
o	Inflammation with secondary edema and distention of the prostatic capsule
o	Poorly localized
	-Lower abdominal
	-Inguinal
	-Perineal
	-Lumbosacral
	-Rectal pain
	-Irritative urinary symptoms (frequency and dysuria)
	-Acute urinary retention

o Poorly localized often means its in the prostate

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6
Q

Penile pain

A

o Pain in the erect penis is usually due to Peyronie’s disease or priapism
o Pain in the flaccid penis
-usually secondary to inflammation in the bladder or urethra
-referred pain that is maximally at the urethral meatus
o Paraphimosis
o Priapism is erection lasting 4-6 hrs í usually Viagra or even sickle cell can cause this
o Peyronie’s Disease upward penile curvature - common
o Paraphimosis í usually an iatrogenic problem; gets edematous and stuck

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7
Q

Testicular pain

A

-Epididymitis
-Torsion of the testicle
o Chronic scrotal pain
-Hydrocele
-Varicocele
-Dull, heavy sensation that does not radiate
-Referred pain to kidneys or retroperitoneum
o Pretty common, differential is wider í is it acute or chronic
o Epididymitis is usually localized to epididymis
o Torsion í usually younger men (high school, etc.) í accompanied with n/v and requires surgical intervention
o Chronic pain í think prostatitis, sometimes epididymitis
-Hydrocele and varicocele tend to be a heavy feeling
-Referred pain usually indicates prostate, not testicle

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8
Q

Lower urinary tract symptoms

A
o	Irritative Symptoms
	-Urinary frequency
	-Nocturia
	-Dysuria
	-Incontinence
	-Stress
	-Urge
o	Obstructive Symptoms
	-Decreased force of urination
	-Urinary hesitancy 
	-Intermittency
	-Post void dribbling 
	-Straining
o	Obstructive is usually seen with prostate enlargement
o	Irritative is usually associated with infection
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9
Q

Infection sxs

A
o	Urethral Discharge: 
	-Most common symptom of venereal infection
o	Fever and Chills:
	-Pyelonephritis
	-Prostatitis
	-Epididymitis (acute)
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10
Q

Past medical history

A

o Systemic diseases that may affect the GU system
-Diabetes Mellitus
-Multiple Sclerosis - due to demyelinating of nerve fibers affecting bladder control.
-TB - reactivation can occur (rarely) anywhere in GU but usually kidney
-Schistosomiasis
o Family history
-Prostate cancer
-Stones (cystine)
-Renal tumors (some types)
o The more first degree relatives that had prostate cancer means your patient has a higher likelihood of having prostate cancer
o Cigarette smoking
-Urothelial carcinoma, mostly bladder cancer
-Erectile dysfunction
o Chronic alcoholism
-Impaired urinary function
-Sexual dysfunction
-Testicular atrophy, decreased libido

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11
Q

physical examination

A
o	General Observations 
"	Visual inspection of the patient 
"	Cachexia 
"	Malignancy, TB
"	Jaundice or pallor 
"	Gynecomastia 
"	Endocrinologic disease 
"	Alcoholism 
"	Hormonal therapy for prostate cancer
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12
Q

physical examination findings: kidneys

A

o The most common abnormality detected on examination of the kidneys is a mass

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13
Q

physical examination findings: bladder

A

o At least 150 ml of urine in it to be felt
o Percussion is better than palpation
o A bimanual examination, best done under anesthesia, is valuable to asses bladder tumor extension

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14
Q

physical examination findings: penis

A
o	The position of the urethral meatus
"	Variations of hypospadius (right)
o	Priapism 
"	sickle cell disease 
"	ED medications
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15
Q

physical examination findings: scrotum and contents

A
o	Painful
"	Torsion
"	Epididymitis
o	Painless 
"	Spermatocele
"	Hydrocele
"	Varicocele
o	Transillumination
"	Cystic vs solid
o	Painless solid testicular mass is tumor until proven otherwise
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16
Q

rectal and prostate examination in the male

A

o Digital rectal examination (DRE):
“ Every male after age 50 years (controversial)
“ Men of any age who present for urologic evaluation

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17
Q

male GU disorders

A
o	Benign Prostatic Hyperplasia (BPH)
o	Erectile dysfunction
o	Hypogonadism
o	Varicocele
o	Hydrocele
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18
Q

Benign prostatic hyperplasia

A

o Common problem
“ 40-50% men aged 51-60 years
“ >80% men >80 years
o Considerable disability
o Low rate of mortality
o Size/volume of the prostate increases with age, leading to symptoms
o If every man lives long enough, his prostate will become enlarged

19
Q

Natural history of BPH

A

o Weight of prostate increases with age
o Muscle cells in the enlarging prostate gland have increased tone
o Urinary flow rates decrease with age
o Post void residual increases due to pressure on the urethra from the prostate
o Develops in the periurethral or transitional zone of the prostate
o Fibromuscular enlargement

20
Q

Diagnosis of BPH

A

o Frequency of urination, nocturia, hesitancy, urgency, weak urinary stream (LUTS)
o Symptoms appear slowly, progress gradually
o Rule out more serious diagnoses before settling with BPH
“ UTI/Prostatitis, urethral stricture, bladder or prostate cancer, bladder calculi, neurogenic bladder
o One of the ways to distinguish BPH from prostate cancer is progression rate í super fast = infection or cancer, BPH is slow
o Urinalysis or urine culture to make sure that prostatitis is not the underlying problem

21
Q

evaluation of BPH

A

o Digital rectal exam - Size, consistency, nodules, induration, symmetry
o Neurologic exam
o Rectal sphincter tone
o Urinalysis - UTI, hematuria
o Serum creatinine - Bladder outlet obstruction, renal/pre-renal dz

o If you examine the prostate and it feels warm and boggy -> most likely prostatitis
o Asymmetrically enlarged -> more worrisome for prostate cancer
o Nodular enlargement -> not normal
o BPH is symmetric, smooth enlargement
o Hematuria could be infection or malignancy

22
Q

Diagnosis of BPH

A

o Serum Prostate Specific Antigen (PSA)
->4.0 ng/mL → look for prostate carcinoma
-Total serum PSA, %free PSA, ratio free-to-total
-% free PSA low in prostate cancer, high in BPH
o Maximal urinary flow rate
-<15 mL/sec indicates obstruction
o Post void residual urine volume
->12 mL abnormal in men

23
Q

Optional studies in BPH

A
o	Pressure-flow studies
o	Urethrocystoscopy
o	Intravenous urography
o	Abdominal ultrasound
o	Abdominal X-Ray (KUB)
o	Reserved for unusual patients
o	Done by Urology Department
24
Q

treatment of BPH

A

o Treat symptoms
o Prevent urinary retention, renal failure
o Treat all men with behavior modification
o Watchful waiting for mild BPH
o Medications for moderate BPH
-α-1-adrenergic antagonists
-5-α-reductase inhibitors
-PDE-5 inhibitors
o Invasive therapy for severe BPH
-TURP most often used
o These should be tailored to symptoms but may include avoiding fluids prior to bedtime or before going out, reducing consumption of mild diuretics such as caffeine and alcohol, and double voiding to empty the bladder more completely. They should also avoid medications that can exacerbate symptoms (eg, diuretics) or induce urinary retention.
o Everyone with BPH need to be couseled on behavior modification like avoiding diuretics, etc.
o Alpha 1 adrenergic antagonists are first line!!, the others are alternative therapy
o Frequent catheters, urinary retention, AUA over 20 need to be recommended for surgery

25
Q

Supplement for mild to moderal BPH

A

o Herbal treatments

- Commonly used in Europe
- Saw palmetto plant extract used most 
- Studies regarding efficacy are controversial
- Not approved by FDA
- No standardization of therapy
26
Q

Medication for moderate BPH: 1st line therapy

A

o α-1-adrenergic antagonists (terazosin, doxazosin)
-Act against the bladder outlet obstruction related to the tension of prostatic smooth muscle
-Receptor density increased in hyperplastic prostate tissue → increased urinary flow
-Improve sxs; No reduction in prostate volume
-Side effects: orthostatic hypotension, dizziness
o Improve symptoms, but don’t actually treat the size of the prostate

27
Q

Medication for moderate BPH

A

o 5-α-reductase inhibitors (finasteride, dutasteride)
-Inhibit conversion of testosterone to dihydrotestosterone
-Improve urinary sxs; Reduce size of the prostate
-Side effects: decreased libido, erectile dysfxn
-Decrease in serum PSA levels
o Combination therapy
-No more effective than single agent @ 6-12 mos
-Longer therapy shown to be more effective
o Combination is recommended for moderate to severe patients -> start with alpha blocker and give them a certain amount of time to see if you get sx improvement and then you can add a 5 alpha reductase

28
Q

treatment for severe BPH

A
o	Transurethral resection of the prostate (TURP)
	-Standard against other treatments
o	Open prostatectomy
o	Urethral stents
o	Laser prostatectomy
o	Microwave hyperthermia
o	Electrovaporization
o	Transurethral needle ablation of the prostate
29
Q

erectile dysfunction

A

o Inability to acquire or sustain erection sufficient for sexual intercourse
o Impotence = symptoms >75% of the time
o Normal male sexual function requires vascular, neurologic, hormonal, and psychological systems to be intact
o Sexual competency requires libido, erection, ejaculation and orgasm

30
Q

erectile dysfunction risk factors

A
o	Cigarette smoking
o	Diabetes mellitus
o	Hypertension
o	Underlying cardiovascular disease
o	Alcoholism or Drug abuse
o	Obesity
o	Depression
31
Q

erectile dysfunction: sexual history

A
o	Rapidity of onset of symptoms
o	Association of local trauma
o	Evaluation of erectile reserve
	-Nocturnal or early morning erection
o	Assessment of interpersonal conflict
o	Past medical history to look for CV or endocrine causes
32
Q

erectile dysfunction: physical examination

A

o Basic CV, Neuro, GU exam
o Femoral and peripheral pulses, femoral bruits
o Breast exam to check for gynecomastia
o GU exam: penile lesions, testicular atrophy, asymmetry or masses
o Other signs of endocrine etiology
-Visual field defects if pituitary tumor suspected
o There could be a pituitary tumor that is squashing their hormones and affecting testosterone

33
Q

erectile dysfunction: laboratory evaluation

A

o Serum testosterone, FSH/LH, prolactin, TSH, PSA, UA, lipid panel, BMP
o EKG
o Nocturnal penile tumescence testing
o Duplex Doppler US or angiography of the penile deep arteries
-Indicated in men with impaired NPT results
o Everyone who you start on PDE5 inhibitor needs an EKG! Need to know!

34
Q

erectile dysfunction: treatment

A
  • Treat the underlying cause(s)
  • Lifestyle modifications to reduce risk factors
  • Restore the capacity to acquire and sustain penile erection
  • Reactivation of libido
  • Medication
  • Penile self-injections
  • Vacuum erection devices
  • Penile prostheses
  • Smoking cessation, abstain from alcohol/drug treatment, DM control, BP control, CV risk reduction, treat endocrine causes such as hypogonadism or prolactinoma, etc.
35
Q

erectile dysfunction: medication

A

o Phophodiesterase-5 inhibitors
-Increase intracavernosal cyclic GMP levels to restore erectile function (vasoactive)
-First-line therapy for ED
-Use with caution in any patient with CV disease
-Contraindicated in patients taking nitrates and α-adrenergic antagonists
o Psychogenic ED
-SSRI’s are first-line therapy
o Screen for CV disease before treating: EKG, lipid panel, BP

36
Q

erectile dysfunction: treatment of refractory ED

A

o Surgical implantation of penile prosthesis reserved for those who fail oral medication and non-oral prescription therapies for ED
o Androgen replacement with oral testosterone for those with documented hypogonadism

37
Q

Hypogonadism

A

o Diagnosis: measure serum total testosterone

- If low, repeat and order LH
- Infertility eval: order semen analysis; if sperm count low, order FSH

o Primary: testosterone and/or sperm count low, LH and/or FSH high
o Secondary: testosterone and/or sperm count low, LH and/or FSH normal or low

o Usually in 40s, 50s, 60s
o Treatment is androgen replacement therapy
o Check PSA in men >50 yrs, Hct
o Contraindications: prostate ca, severe OSA, Hct >50%, severe LUTS, uncontrolled CHF
o ADE: inc PSA, worse BPH, erythrocytosis, worse OSA
o FU: at 2-3 mos, then q 6-12 mos
-Serum testosterone, serum LH if primary hypogonadism, Hct, PSA
o Recommended for symptomatic men with documented hypogonadism

38
Q

varicocele

A

o Collection of dilated and tortuous veins in the pampiniform plexus surrounding the spermatic cord
o Etiology is increased venous pressure and incompetent valves
o 10-25% adolescents
o Occurs more often on the left side
o Problematic if its on the right side
o Very common on the left
o If it doesn’t resolve when the pt lies down, its worse, more severe

39
Q

varicocele: clinical presentation

A

o Usually asymptomatic; Symptoms may include dull ache or fullness in scrotum on standing
o On PE: spermatic cord has a “bag of worms” that increases with Valsalva or standing
o Graded based on size
-Grade 1: small; palpable only with Valsalva
-Grade 2: moderate; not visible on inspection, but palpable upon standing
-Grade 3: large; visible on gross inspection

40
Q

Varicocele: management

A

o Most can be managed with observation
o Abnormal if right sided, acute onset, or persist when supine
-Order Doppler US
-Consider IVC obstruction (IVC thrombus, right renal vein thrombosis, abdominal mass)
o Want to refer to urology if its on the right side or doesn’t resolve when they lie down
o Right side is usually in older men

41
Q

varicocele: surgical management

A

o Cosmetic
o Pain
o Infertility
o Testicular Atrophy
o Surgical ligation or testicular vein embolization
-Affected testicle smaller than unaffected side
-Bilateral varicocele
-Grade 3 varicocele
-Scrotal pain is present
o Cosmetic not usually covered by insurance

42
Q

hydrocele

A

o Fluid accumulation in the potential space of the tunica vaginalis
o Etiology
-Peds: Failure of the processus vaginalis to close during development
-Adult: Secondary to epididymitis, orchitis, testicular torsion, torsion of the appendix testis, tumor, or trauma

43
Q

hydrocele clinical presentation

A

o Soft, cystic, anterior scrotal mass
o Hydroceles that communicate with the peritoneal cavity increase during the day, disappear at night
o Non-communicating hydroceles are not reducible, do not change with straining
o Exam of the scrotum reveals soft, cystic anterior mass that transilluminates to indicate fluid
o Doppler US may be needed to rule out another primary etiology

44
Q

management of hydrocele

A

o Treat any primary underlying cause
o Non-communicating hydrocele in children
-< 2 years is supportive care
o Communicating hydrocele poses risk for incarcerated inguinal hernia
o Surgical repair for children > 2 years or if scrotum is tense to improve blood flow to testicles
-Case 5