Male genital system 2

Question 1

____ is the most common germ cell tumor of the testis#

Answer 1

Seminoma

Question 2

Gross appearance of seminomas

Answer 2

grossly homogenous, not typically necrotic or hemorrhagic

Question 3

Histo appearance of seminomas

Answer 3

Distinct cell membrane and clear cytoplasm–> fried egg

Question 4

Seminomas are associated with an increase in what?

Answer 4

hCG and..

Placenta like alkaline phosphatase (PLAP)#

Question 5

How do seminomas metastasize?#

Answer 5

lymphatics

Question 6

Epidemiology of seminomas#

Answer 6

Males 15-35, increase risk with cryptorchidism

Question 7

Which is most likely to be a pure tumor- embryonal carcinoma or seminoma?

Answer 7

seminoma

Question 8

Which is more aggressive, seminoma or embryonal carcinoma

Answer 8

carcinoma

Question 9

Gross appearance of embryonal carcinoma

Answer 9

more likely to be hemorrhagic or necrotic, ill-defined

Question 10

Histo appearance of embryonal carcinoma

Answer 10

sheets, alveoli, tubules, or papillary formations– anaplastic looking,

Question 11

Epidemiology of yolk sac tumors

Answer 11

almost exclusively a tumor or infants and children up to 3 years of age. In adults more commonly seen mixed with other gem cell tumor patterns.

Question 12

What is the main distinguishing feature of yolk sac tumors?

Answer 12

production of AFP (can be seen on immunohistochemical stain

Question 13

Testicular tumors metastasize first to the _____.#

Answer 13

periaortic lymph nodes

Question 14

Describe yolk sac tumors histologically#

Answer 14

cells appear cuboidal to columnar, often associated with hyaline globules and Schiller-Duval bodies

Question 15

Gross appearance of choriocarcinoma

Answer 15

#small and non-palpable
Very vascular--> metastasis will bleed easy

Question 16

Describe choriocarcinoma

Answer 16

only 1% of germ cell tumors are pure chorio, bu chorio is commonly represented in mixed germ cell tumors. Highly aggressive. Produced HCG

Question 17

Describe histo appearance of choriocarcinoma

Answer 17

mimics the histology of normal placenta- syncitiotrophoblast and cytotrophoblast and produces hcg