Male Genital Pathology Flashcards
Basic Principles of Testicular Masses (3)
1) Don’t Biopsy - Risk of Seeding
2) Firm + Painless Mass
3) Cannot by trans-illuminated (vs. hydrocyle which can be)
Testicular Germ Cell Tumors - 2 Major Classes + 5 Major Types
Classes –> Seminomas (Germ Cells aka Sperm) vs. Non-Seminoma (Other Cells)
1) Seminioma - Germ Cell
2) Embryonal Cercinoma - Non-Seminoma
3) Yolk Sac (Endodermal Sinus) Tumor - Non-Seminoma
4) Choriocarcinoma - Non-Seminoma
5) Teratoma - Non-Seminoma
Seminoma - Type of Tumor + Key Features (3)
Malignant tumor of spermatogonia –> Forms s homogenous mass with no hemorrhage or necrosis
Features
1) No Necrosis + Hemorrhage
2) Most Common
3) Good Prognosis
Embryonal Carcinoma - Type of Tumor + Key Features (2)
Non-Seminoma - Malignant tumor of immature primartive cells - becomes a bloody mess
1) Aggressive with early hematogenous spread (embyro-like - wants to spread)
2) Blood mass with necrosis
Yolk Sac Tumor - Type of Tumor + Key Features (3)
Non-Seminoma - Malignant tumor of yolk sac elements
1) Most common testiculartumor in children
2) Schiller Duval-Bodies (Glomerulus LIke)
3) AFP Characteristically Elevated
Choriocarcinoma - - Type of Tumor + Key Features (3)
Non-Seminoma - Malignang tumor of cyncyliotrophoblasts (placenta like without villi)
1) Spreads early via blood - lots of metastasis (small testicular lesion with large lesions elsewhere)
2) Beta-HCG Characteristically elevated
3) Elevated Beta-HCG Linked to hyperthroidism + Gynecomastia
Teratoma - Type of Tumor + Key Features (1)
Non-Seminoma - Mature fetal tumor with 2-3 embryonic layers
1) Malignant in males vs. benign in females
Sex-Cord Stromal Tumors - Tumor Type + Major Classes (2)
Benign tumors of the sex cord stromal tissue
1) Leydig Cell Tumor –> Androgen Producing causin precocious puberty + Reinke Crystals in Histology
2) Seritoli cell Tumor
Lymphoma of the Testicles - Key Points (2)
1) Most common testicular tumor > age 60
2) Usually Diffuse Large B-Cell
