Male Development Flashcards
What protein is produced when the SRY gene is expressed?
Testis Determining Factor (TDF)
Sertoli cells produce what hormone?
Anti-Mullerian Hormone (or Mullerian Inhibiting Substance)
Leydig cells produce what hormone?
Testosterone
Syncytiotrophoblasts produce this hormone
Human Chorionic Gonadotropin
Human Chorionic Gonadotropin stimulates ____________ cells to produce _______________
Leydig, Testosterone
Defective MIS receptors result in ______________ syndrome.
Persistent Mullerian Duct
Complications of Persistent Mullerian Duct Syndrome may include ____________ and ____________.
Cryptorchidism, sterility
The presence of Anti-Mullerian Hormone results in _____________________.
Degeneration of the Mullerian duct.
Testosterone signals the mesonephric duct to ________ and _________.
Survive, grow
The conversion of testosterone to dihydrotestosterone by 5-alpha-reductase is important for the development of these glands: __________, _________, __________.
Prostate, seminal vesicle, bulbourethral
Germ layers that make up the genital tubercle
Ectoderm, lateral plate mesoderm, endoderm
The prostate gland develops from the _________ epithelium of the _________.
Endodermal, urogenital sinus (pelvic portion)
The bulbourethral gland develops from the _______ epithelium of the _________.
Endodermal, urogenital sinus (pelvic portion)
The seminal vesicle develops as a bulbous swelling from the ___________.
Mesonephric duct
The Mullerian ducts degenerate via the active process of ______________.
apoptosis
Due to the concentration gradient of Anti-Mullerian Hormone, the Mullerian duct degenerates in a _______ to _________ direction.
cranial, caudal
The elongation and subsequent convolution of the portion of the mesonephric duct closest to the developing testes forms the ______________.
epididymis
Under the influence of the products of TDF expression, the cells of the mesothelium that have penetrated the gonadal ridge and enveloped the PGCs differentiate into _________________.
Sertoli cells
While the endodermal epithelium of the UG sinus forms the glandular portion of the prostate, the _________ differentiates into the connective tissue and ___________ of the prostate.
mesenchyme, smooth muscle
Prior to migration along the dorsal mesentery, the primordial germ cells are located in _________________ close to the ___________.
endoderm of the yolk sac, allantois
The rete testis is the anastomoses of the ________ and the ________.
straight tubules, efferent ducts
After the testis cords separate from the epithelium, a thick, fibrous layer of connective tissue called the ____________ separate the cords from the surface epithelium.
tunica albuginea
