Malaria - current clinical treatment and drug discovery

Question 1

Types of treatment (3)

Answer 1

Therapeutic
Gametocidal
Radical

Question 2

What is the treatment for the hypnozoite stage?

Answer 2

Primaquine

Question 3

Which species of plasmodium has a hypnozoite stage?

Answer 3

P. vivax

Question 4

What are the species of plasmodium that infect humans?

Answer 4

P. malariae
P. vivax
P. ovale
P. knowlesi
P. falciparum

Question 5

Which species of plasmodium is associate with acute malaria?

Answer 5

P. falciparum

Question 6

What do therapeutic treatments do?

Answer 6

Eliminate merozoites in erythrocytic phase

Question 7

What is the purpose of therapeutic treatments?

Answer 7

Preventative - no useful if live in endemic area (for travellers)

Question 8

What are the two types of potential vaccine currently being investigated?

Answer 8

Transmission-blocking vaccine (TBV)

Genetically attenuated parasite (GAP)

Question 9

Current prescribed treatment for uncomplicated malaria

Answer 9

Artesunate and Mefloquine combination therapy (aka. an Artemisinin-based Combination Therapy (ACT))

Question 10

Current clinical treatment for P.ovale and P.vivax

Answer 10

Chloroquine

Question 11

Which drug treatment is currently preferred and being further explored?

Answer 11

Artesunate and Mefloquine combination therapy (aka. an Artemisinin-based Combination Therapy (ACT))