Malabsorbtion - Coeliac's

Question 1

Disorders of malformation classically manifest as;

Answer 1

1. Abnormal stool
2. Failure to thrive and poor growth
3. Nutrient deficiencies

Question 2

What is the mechanism behind coeliac’s disease?

Answer 2

1. Gliadin provokes an immunological response against the small intestinal mucosa
2. Damages villi and causes crypt hyperplasia

Question 3

What age does coeliac’s disease classically present at?

Answer 3

8 - 24 months of age after the introduction of wheat containing foods

Question 4

Typical clinical symptoms of a child presenting with coeliac’s

Answer 4

1. Abdominal distention
2. Abnormal stool
3. General irritablity

Question 5

What are some clinical signs of a child presenting with coeliacs?

Answer 5

1. Failure to thrive

2. Anaemia / iron or folate deficiency

Question 6

What is an alternative way for children to be identified?

Answer 6

Screening of children who are at increased risk

• Type 1 diabetets
• Autoimmune thyroid disease
• Down syndrome

Question 7

Investigation for coeliacs disease?

Answer 7

1. Serological tests - igA tissue transglutaminase antibodies and endomysial antibodies may be found

DIAGNOSIS CAN ONLY BE MADE IF

2. Small intestinal biopsy is performed and shows
   * * subtotal villous atrophy **

Question 8

Mx

Answer 8

Gluten free diet