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NUAN 604- Intro to Sim > Maintenance Meds Quiz > Flashcards

Maintenance Meds Quiz Flashcards

1
Q

What is the trade name of Cisatracurium?

A

Nimbex

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2
Q

What is the mechanism of action of Cisatracurium?

A

Competitive Ach receptor antagonist (Ach nicotinic antagonist)

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3
Q

What is the maintenance and infusion dose of Cisatracurium ?

A

Maint: 0.03mg/kg/IV
Infusion: 1-2 mcg/kg/min

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4
Q

How is Cisatracurium metabolized?

A

Hoffman Elimination (77%) & renal (16%)

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5
Q

What is the trade name of Dexmedetomidine?

A

Precedex

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6
Q

What is the indication for use of Dexmedetomidine?

A

Decrease the need for narcotics and maintains respiratory stability

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7
Q

What is the loading dose range for Dexmedetomidine?

A

0.5-1mcg/kg/IV over 10mins

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8
Q

What is the mechanism of action of Dexmedetomidine?

A

Selective alpha2 receptor agonist

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9
Q

What is the trade name of Ephedrine?

A

Generic only/No brands available

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10
Q

What are the contraindications for Ephedrine?

A

Causes tachyphylaxis (repeated doses that can become ineffective)

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11
Q

What is the dose range for Ephedrine?

A

2.5-10mg/IV

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12
Q

What is the mechanism of action of Esmolol?

A

Short acting beta 1 antagonist

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13
Q

What is the trade name of Fentanyl?

A

Sublimaze

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14
Q

What is the primary use of Fentanyl?

A

Adjunct for induction or maintenance analgesia

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15
Q

What is the dose range for Fentanyl?

A

1-3 mcg/kg low
5-10 mcg/kg med
20-50 mcg/kg high
75 mcg/kg for CABG

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16
Q

What is the metabolism pathway for Fentanyl?

A

CYP450 Liver

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17
Q

What is the trade name of Hydromorphone?

A

Dilaudid

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18
Q

What is the indication for use of Hydromorphone?

A

Moderate to severe post op pain

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19
Q

What is the standard dose of Hydromorphone?

A

0.01-0.02 mg/kg

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20
Q

What is the trade name of Ketamine?

A

Ketalar

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21
Q

What is a significant contraindication for Ketamine?

A

Head Injury / Increased ICP

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22
Q

What is the mechanism of action of Ketamine?

A

N-methyl-D-aspartate (NMDA) receptor antagonist
It interferes with communication between the limbic and thalamus, causing a dissociative state

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23
Q

What is the standard dose of Ketamine?

A

1-2mg/kg/IV

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24
Q

What is the trade name of Ketorolac?

A

Toradol

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25
What is the primary indication for Ketorolac?
Postoperative pain
26
What is the dose range for Ketorolac?
30 mg/IV Q 6 hrs. 15 mg can be just as effective
27
What is the mechanism of action of Labetalol?
Blocks activity at both alpha and beta receptors 1:7 (more beta)
28
What is the trade name of Morphine?
Duramorph / Astromorph / MSO4
29
What is the mechanism of action of Morphine?
Mu receptor agonist to produce analgesia
30
What is the standard dose of Morphine?
0.03-0.15 mg/kg
31
What is the trade name of Ofirmev?
Tylenol
32
What is the indication for Ofirmev?
Postoperative pain decrteases use of opioid adn reduces indicende of PONV
33
What is the dose range and maximum dose of Ofirmev in 24 hours?
1000 mg Q6 and max 4000 mg
34
What is the mechanism of action of Phenylephrine?
Direct acting alpha-1 adrenergic agonist sympathomimetic effects
35
What is the trade name of Remifentanil?
Ultiva
36
What is a key contraindication for Remifentanil?
Hypersensitivity to fentanyl analogs not for epidural or intra-thecal administration Can cause opioid induced hyperalgesia
37
What is the standard dose range for Remifentanil?
Bolus: 1mcg/kg over 30-60 sec; Infusion: 0.05-2mcg/kg/min
38
What is the trade name of Rocuronium?
Zemuron
39
What is the mechanism of action of Rocuronium?
Competitive Ach receptor antagonist nicotinic antagonist
40
What is the maint and infusion dose range for Rocuronium?
Maint- 0.15 mg/kg Infusion- 9-12 mcg/kg/min
41
What is the trade name of Sufentanil?
Sufenta
42
What is the potency of Sufentanil compared to Fentanyl?
10x more potent than fentanyl
43
What is the standard dose of Sufentanil?
0.25 mcg/kg
44
What is the mechanism of action of Vecuronium?
Competitive Ach receptor antagonist
45
What is the infusion dose range for Esmolol?
50-200 mcg/kg/min
46
what is the indication for Nimbex?
NDMR
47
What are the contraindications for Nimbex?
no adverse cardiovascular effects
48
what is the maintenance dose for Precedex?
0.4-0.7 mcg/kg/hr
49
what are the contraindications for Precedex?
bradycardic or hypotensive patients
50
what is the concentration of Precedex?
100mcg/mL
51
what is the concentration of cisatracurium?
2mg/mL OR 10 mg/mL
52
what is the concentration for Ephredine?
5 mg/mL OR 10 mg/mL
53
what is the indication for use of ephedrine?
treatment for hypotension WITH Bradycardia
54
what is the other name for Esmolol?
Brevibloc
55
what are the indications for Esmolol?
treatment for SVT, tachycardia, HTN, myocardial ischemia Good for hypertensive patients with asthma due to beta 1 short acting
56
what are contraindications for Esmolol?
compromised myocardial function such as CHF or cardiogenic shock Also bradycardia and heart block
57
what is the loading and infusion doses of Esmolol?
Loading- 0.5mg/kg Infusion- 50-200 mcg/kg/min
58
what is the concentration of esmolol
5 mg/mL
59
what is the metabolizm of esmolol
Rapid distribution and hydrolysis by RBC Estrase
60
what is the concentration of fentanyl
50 mcg/mL
61
what does fentanyl agonize
mu receptors to produce analgesia
62
what is a contraindication of hydromorphone?
caution in severe asthmatics
63
what is the standard concentration of Hydromorphone?
2 mg/mL
64
how is hydromorphone metabolized?
conjugation in liver excreted by kidneys
65
what is the indication of ketamine?
induction or adjunct to MAC strong bronchodilator somatic over visceral analgesic
66
what is the MOA of ketamine?
interferses with communciation with limbic and thalamus causes a dissociative state NMDA receptor antagonist
67
what is the concentration of ketamine
50 mg/ML
68
how is ketamine metabolized
liver hepatic microsomal enzymes
69
what are contraindications of ketoralac
may prolong bleeding time reduce dose in elderly renal insufficiency and aspirin induced asthma
70
how is toradol metabolised
liver by hydroxylastion and conjugation and excreted by kidneys
71
what concentration does Ketoralac come in
30 mg/mL
72
what are the trade names of Labetolol
normodyne trandate
73
what is labetol
an antihypertensive drug
74
what is the dose or dose range for Labetolol
bolus 2.5-10 mg over 2 min infusion 0.5-2mg/min
75
what is the standard concentration of labetalol
5mg/mL
76
how is labetolol metabolized
conjugated of glucuronic acid
77
how is ofirmev metabolized?
Liver by first-order kinetics 3 Pathways: -Conjugation w/ Glucuronide -Conjugation w/ Sulfate -Oxidation via the CYP450
78
what is the contraindication of Ofirmev
children <2 years not for severe active liver disease or liver failure
79
what is the MOA of ofirmev?
unclear- inhibition of cyclooxygenase (COX), with a predominant effect on COX-2
80
what is the standard concentation of ofirmev
10mg/ml
81
what ist he trade name for phenylephrine
neosynephrine
82
what is the indication of phenylephrine
treatment for hypotension with increased HR Used for nasal decongestion OTC Beneficial in cardiac ischemia patients
83
what is a contraindication of phenylephrine
it can cause reflex bradycardia
84
what is the dose range for phenylephrine
bolus 50-100 mcg infusion 0.25-1mcg/kg/min
85
what is the standard concentration of phenylephrine
100 mcg/ml DILUTED from 10 mg/mL
86
how is phenylephrine metabolized?
liver by Monoamine Oxidase and SulfoTransferase NEO does the MOST
87
what is the indication for remifenantyl
Recommended for procedures < 30 min Short-acting synthetic opioid: analgesia and adjunct for GA
88
what is the standard concentration of remifentanyl?
Reconstitute 2000 mcg vial 25-50mcg/mL
89
how is remifentanyl metabolized?
plasma erythrocyte and tissue esterase's PETER
90
what is the MOA of remifentanyl
agonizes MU receptors to produce analgesia
91
what is the trade name for rocuronium
zemuron
92
what indication is roc for
NMDR
93
what standard concentration is ROC
10 mg/mL
94
how is rocuronium metabolized
>70% eliminated by biliary excretion & 10-25% by kidney
95
what is the MOA for sufenta
agnoizes mu receptors to proudce analgesia
96
waht concentration does sufenta come in
50 mcg/ml
97
how is sufenta metabolized
liver CYP34A and small intestines
98
what is the trade name for vecuronium
norcuron
99
what ist he indication for vec
NDMR
100
what contraindications does vecuronium have
No adverse circulatory effects Don’t use in renal or liver disease
101
what is the dose range for vec
Maint; 0.01 mg/kg Infusion; 1-2 mcg/kg/min
102
what is the standard concentration for VEC
20 mg powder = 2mg/ml OR 10 mg powder = 1mg/ml
103
how is VEC metabolized
40-50% hepatic & 50-60% renal

NUAN 604- Intro to Sim (3 decks)

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