Maintaining A Balance Flashcards
What is activation energy?
The energy required for a reaction to take place, enzymes lower the activation energy required.
What are enzymes?
Enzymes are biological catalysts, present in living systems.
What is a substrate?
The reactant in an enzyme catalysed reaction.
What is the chemical nature of enzymes?
Enzymes are proteins which means that they are amino acids bonded to form polypeptides, these polypeptides(either one or more) compose a protein by folding into a3-dimensional shape. Enzymes also posses an active site.
Models used to describe specificity of enzymes?
Lock and key(rigid active site)/induced fit(flexible active site)
What are Cofactors?
Inorganic ions that help enzymes to act.
What are coenzymes?
Organic molecules which help enzymes to act.
Effect of temperature on Enzymes activity?
Enzymes have an optimum temperature where they can act at their maximum capacity, if the temperature increase they undergo denaturation if it’s extreme, and become sluggish if it’s to cold.
What is denaturation?
Ii when heat breaks the peptide bonds the hold the amino acids together, rendering the active inactive and the 3-dimensional shape of the protein is lost.
What is pH?
Hydrogen ion concentration.
What is the effect of pH on enzyme activity?
Enzymes have a. Limited pH range which they are active in , outside of this the the enzymes molecules are distorted and the activity is reduced.
What is the effect of Substrate concentration on enzymes?
Substrate concentration increase to create a saturation point, enzyme activity will not increase beyond this point.
What is the role of Enzymes in the metabolism?
To accelerate the metabolic pathway by lowering the activation energy of each reaction at each stage. This allows the synthesis of compound to be quicker, feedback loops often control enzymes to meet the needs of the organism’s metabolism.
World equation for cellular respiration?
Glucose + oxygen results in carbon dioxide + Water + ATP
Reaction works by the oxidation of glucose which is catalysed by the enzyme hexokinase to create the product water, carbon dioxide and ATP.
What is hexokinase?
The enzymes that catalyses cellular respiration.
What is homeostasis?
The maintenance of a constant internal environment.
Explain why maintaining a constant internal environment is important to optimal metabolic efficiency?
If the internal environment (temperature, pH, substrate concentration) does not remain relatively stable, then the rate of enzyme-catalysed reactions decreases. This decreased rate could affect an entire metabolic pathway that might produce an essential compound such as haemoglobin, ATP etc.
What is metabolism?
Sum of all chemical reactions?
What is feedback?
I activity of key enzymes is regulated to control the metabolism.
What are the four steps of feedback loop?
Set value, detector, control centre and regulator/effector.
How does the detector/receptor work?
It is a sensor that monitors changes in stimuli(internal and external) initiates a response to them though a larger feedback loop.
How does the control centre work?
The control centre is biologically programmed to maintain the set value, it analyses the messages sent and determines and approiate response which is send via and effector.
What are the two stages of homeostasis?
Detecting changes from a stable state and counteracting changes from the stable state.
What are the two types of feedback?
Positive and negative.
What is negative feedback?
Is a set value or point deviates from this value, negative feedback cause the system to to correct the deviation and return the value to the set value. Negative feedback countered acts the change,
What is positive feedback?
Positive feedback cause the system to reinforce the change, postive feedback reinforces the change.
Range if blood pH in human body?
7.38-7.42
Internal conditions controlled by nervous system?
Blood pressure and concentration of respiratory gases(co2 and O2) in blood.
Internal conditions controlled by endocrine system?
Blood glucose levels.
Internal conditions controlled by nervous and endocrine system?
Temperature, concentration of salt and water in blood and tissue.
Blood sugar feedback mechanism?
Set value=90mg/100ml
detector = specialised receptor cells pass message to pancreas
Control centre= pancreas excretes insulin
Effector = insulin when realised into circulatory system.
Y is homeostasis important?
The importance of homeostasis is that it maintains the concentration of metabolites and/or physical conditions within a narrow range that enables cells to function efficiently.
What is the endocrine system?
Series of glands that excrete hormones.
Features of hypothalamus that control homeostasis in relation to internal systems controlled nervous system or a combination of nervous and endocrine system?
Detector/report cells directly connected to neurons which relay message to hypothalamus and the hypothalamus directly controls regulatory organs and glands though nervous and endocrine system.