MAGPIE

Question 1

Do women with PET and their babies benefit from MgSO4 (MAGPIE)

Answer 1

RCT
N 10141
175 centres, 33 countries low and high income
Lancet 2002

Incl criteria:
BP >140/90 on  2 readings + protein  1+ antepartum or within 24hrs postpartum and clinical uncertainty if MgSO4 needed – randomised to:
- MgSO4
- Placebo

Exclusion: hypersensitive, myasthenia graves

Question 2

Primary Outcomes: Do women with PET and their babies benefit from MgSO4 (MAGPIE)

Answer 2

Primary outcome:

• Eclampsia [0.8% vs 1.9%; 58% lower risk with 11 fewer cases/1000 women; NNT 91]
• Maternal mortality [Trend towards dec - 0.2% vs 0.4%; p = 0.11; RR 0.55]
• NND [no diff but dec in placental abruption – 2% vs 3.2%; RR 0.67  12 fewer cases/1000 women]

Question 3

Secondary Outcomes: Do women with PET and their babies benefit from MgSO4 (MAGPIE)

Answer 3

• Maternal morbidity
• Toxicity
• SEs (25% got SEs)
• If randomised before birth – also labour complications and NN morbidity

 Overall no diff
(Small inc LSCS with MgSO4)