Magnetic Resonance Imaging 1 Flashcards

1
Q

What is nuclear magnetic resonance (NMR)?

A

spectroscopic technique which examines the radiofrequency (RF) emissions from spinning (precessing) nuclei

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2
Q

What is the spectroscopic technique?

A

uses an interrogating RF field to ascertain the magnetic moments of nuclei. Resonance ensures that only the nuclei of a particular element respond to the RF.

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3
Q

How does MRI extend the spectroscopic technique?

A

to image the distribution of a particular nucleus (ie. hydrogen - the intensity of the proton frequency emission) throughout the body.

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4
Q

Why is hydrogen chosen in MRI?

A

it demonstrates strong nuclear magnetic resonance and because of its prevalence in the body (through H2O).

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5
Q

What are paramagnetic substances?

A

When freely suspended in the presence of an external magnetic field, diamagnetic substances align themselves with the external field and become magnetised in a direction parallel to it. The net effect is an increase in the field strength around the material. This is a temporary effect and returns to its equilibrium distribution when the field is removed (eg. aluminium)

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6
Q

What are diamagnetic substances?

A

When freely suspended in the presence of an external magnetic field, diamagnetic substances align themselves against the external field and become magnetised in a direction opposite to it. The net effect is a reduction in the field strength around the material. This is a temporary effect and returns to its equilibrium distribution when the field is removed. (eg. water, nitrogen)

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7
Q

What are ferromagnetic substances?

A

are those which demonstrate very strong paramagnetism, to the extent that the magnetic forces may be sufficient to move the material to a stronger part of the field. Such substances retain their magnetisation following removal of the field. (eg. iron)

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8
Q

What is electromagnetism?

A

Copper is not strongly magnetic itself, but it can be made to exhibit strong magnetic fields by passing a current through it. This is the principle of the electromagnet, and a ferromagnetic core by virtue of its strong magnetisation adds to the field strength. The magnetic field due to the current is not related to the copper itself, but is a property of moving charges - a fundamental effect that can be described by a relativistic argument.

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9
Q

What is electromagnetism?

A

A moving charge has an associated B-field

Field at centre of a current loop

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10
Q

What is the Biot-Savart Law?

A

look at poster

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11
Q

What is precession?

A

Precesses in response to an applied torque
Precession is in a plane orthogonal to plane of couple
Rotating direction of spinning mass affects direction of precession
The greater the applied torque, the faster the precession

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12
Q

What is the difference between linear and rotational mechanics?

A

Force = rate of change of linear momentum

Torque = rate of change of angular momentum

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13
Q

What is the process of precession?

A
Proton is a spinning, rigid body
Apply B-field
Proton attempts to align
Proton precesses…
...swept, accelerating charge
Maxwell
Proton radiates
(w=B) w is ‘Larmor frequency’
Bloch equations
dM/dt = yMxB
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14
Q

What is the simplistic classical MR model of precession?

A

Proton: Charged body, Rigid body, Intrinsic spin
Applied B-fiel: Precession, Radiated RF
Detection: Tuned RF sense coils
Proton density signal

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15
Q

Why would there be no signal?

A

Body composed of many spins
Randomly orientated
All orientations equally represented

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16
Q

What is phase incoherence?

A

Many protons
RF signal emitted from each
Complete phase cancellation
No net RF power detected

17
Q

What happens when phase coherence is explored?

A

Apply B-field
Spins attempt to align
Small alignment = magnetization
Aligning torque = precession

18
Q

In some phase coherence, how is ther a detectable signal?

A

by ultilisaing asymmetry of magnetisation
Drive z-magnetization into the precessional plane
Use precession
Resonance
B-component of incident RF -> absorbed by sample

19
Q

What is relaxation?

A

A function of asymmetry in precessional plane
Asymmetry relaxes to return to equilibrium condition
Two independent relaxations
Transverse (spin-spin) – T2 (fast)
Longitudinal (spin-lattice) – T1 (slow)
Exponential in nature