Macrophages

Question 1

3 examples of DAMPs?

Answer 1

ATP, HSPs and ECM proteins

Question 2

What is classical macrophage activation?

Answer 2

LSP and INF-gamma

Question 3

What does classical activation cause macrophages to secrete?

Answer 3

TNF-alpha, CD86, NO, H202, IL-6, MHC11, IL-23

Question 4

What does IL-23 stimulate?

Answer 4

Th17

Question 5

What does regulatory macrophage secrete?

Answer 5

IL-10, TNF-beta

Question 6

What is wound healing macrophage activated by?

Answer 6

IL-4, IL-13 MHCII and arginase.

Question 7

What happens to arginase?

Answer 7

Converted to ornithine - precurser to collagen

Question 8

What are opsonic receptors?

Answer 8

FcRS, CR3

Question 9

What causes phagosome maturation

Answer 9

Rab7/9 and cathspin

Question 10

What antimicrobial killing mechanisms do macrophages use?

Answer 10

Short 15-20 base amino acids which bind electrostatically to target and form pores.

Question 11

What nutrient deprivation occurs?

Answer 11

lactoferrin, SAMHD1, Vit-B12 binding protein.

Question 12

What proteolytic activity occurs?

Answer 12

V-ATPase, INF-gamma, lysozymes, caspase D and lipase