macrolides

Question 1

point

Answer 1

-thromycin. (erythromycin, azithromycin, clarithromycin)

fidoxomicin (new use to treat c.diff)

Question 2

mechanism

Answer 2

use to bacteriostatic by inhibit protein synthesis, the target 50S

Question 3

treat

Answer 3

bacterial infection
- respiration
- sinus
- GI
- skin
- otitis
- conjunctivitis
diarrhe
STI

comman use for patient allergic to penicillin

Question 4

adverse

Answer 4

• prolonged QT interval หัวใจเต้นผิดจังหวะ
• hepatotoxicity ( moniter AST, ALT) ตับ
• GI distress
• c diff
• diarrhea
• increase drug level drug level warfarin, carbamazepine, theophylline