Macrocytic Anaemia Flashcards
1
Q
A malabsorption cause of vitamin b12 deficiency?
A
Lack of intrinsic factor which is produced by gastric parietal cells, seen in pernicious anaemia.
Autoimmune destruction of parietal cells.
2
Q
Causes of megaloblastic anaemia?
A
B12 deficiency
Folate deficiency
3
Q
Characteristics of megaloblastic blood film?
A
Hypersegmented polymorphs (neutrophils)
So you’d see this in pernicious anaemia for example.
4
Q
Causes of macrocytosis without megaloblastic change?
A
Alcohol most common cause
5
Q
Who is prone to b12 deficiency?
A
Vegans
6
Q
Causes of folate deficiency?
A
Alcohol
Increased demand: Pregnancy, haemolytic anaemia, cancer
Malabsorption: coeliac disease
