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Microbiology > M6: Key Pharmacokinetic Properties of Antibiotics > Flashcards

M6: Key Pharmacokinetic Properties of Antibiotics Flashcards

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1
Q

Non-Renal Elimination (7)

Most antibiotics require dose adjustments in
renal insufficiency, except for these

A 
Azithromycin 
Beta-lactams (ceftriaxone, naf/ox) 
Clindamycin 
Moxifloxacin 
Rifampin 
Tetracyclines 
Fidaxomicin
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2
Q

Elimination Dependent on Hepatic Function (6)

Require dose adjustment or close monitoring
in hepatic insufficiency

A 
Tigecycline 
Rifampin 
Nafcillin/Oxacillin 
Ceftriaxone 
Metronidazole 
Clindamycin
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3
Q

Good/Very Good Oral Absorption (10)

*Concurrent administration of di- and tri-valent cations decrease absorption (via chelation)

A 
Clindamycin 
Fluoroquinolones* 
Linezolid 
Metronidazole 
Nitrofurantoin 
Tetracyclines* 
Rifampin 
TMP/SMX 
Beta-lactams (good) 
Macrolides
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4
Q

Minimal Oral Absorption (4)

A

Aminoglycosides
Polymyxins
Vancomycin
Fidaxomicin

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5
Q

Wide Distribution (excellent CSF penetration) (4)

A

Metronidazole
Rifampin
TMP/SMX
Linezolid

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6
Q

Moderate Distribution (good CSF penetration) (9)

A 
Vancomycin 
Select Beta-lactams 
-ceftriaxone 
-cefuroxime 
-ceftazidime 
-cefepime 
-imipenem 
-meropenem 
Fluoroquinolones
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7
Q 
Poorly Distributed (4)
*(only for cystitis due to low systemic levels)
A

Aminoglycosides
Daptomycin
Polymyxins
Nitrofurantoin*

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8
Q 
Azithromycin 
Beta-lactams (ceftriaxone, naf/ox) 
Clindamycin 
Moxifloxacin 
Rifampin 
Tetracyclines 
Fidaxomicin
A

Non-Renal Elimination (7)

Most antibiotics require dose adjustments in
renal insufficiency, except for these

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q 
Tigecycline 
Rifampin 
Nafcillin/Oxacillin 
Ceftriaxone 
Metronidazole 
Clindamycin
A

Elimination Dependent on Hepatic Function (6)

Require dose adjustment or close monitoring
in hepatic insufficiency

How well did you know this?
1
Not at all
2
3
4
5
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10
Q 
Clindamycin 
Fluoroquinolones* 
Linezolid 
Metronidazole 
Nitrofurantoin 
Tetracyclines* 
Rifampin 
TMP/SMX 
Beta-lactams (good) 
Macrolides
A

Good/Very Good Oral Absorption (10)

*Concurrent administration of di- and tri-valent cations decrease absorption (via chelation)

How well did you know this?
1
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3
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11
Q

Aminoglycosides
Polymyxins
Vancomycin
Fidaxomicin

A

Minimal Oral Absorption (4)

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12
Q

Metronidazole
Rifampin
TMP/SMX
Linezolid

A

Wide Distribution (excellent CSF penetration) (4)

How well did you know this?
1
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2
3
4
5
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13
Q 
Vancomycin 
Select Beta-lactams 
-ceftriaxone 
-cefuroxime 
-ceftazidime 
-cefepime 
-imipenem 
-meropenem 
Fluoroquinolones
A

Moderate Distribution (good CSF penetration) (9)

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14
Q

Aminoglycosides
Daptomycin
Polymyxins
Nitrofurantoin*

A 
Poorly Distributed (4)
*(only for cystitis due to low systemic levels)
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Microbiology (36 decks)

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