M103 T2 L3 Flashcards
Where are erythrocytes made in the body?
bone marrow
(marrow, Centri, prox ends)
centripetal bones
the proximal ends of long bones
How many RBCs are made in the body per second?
about 5 million RBCs per second
What are three common causes of iron deficiency?
chronic blood loss (most common cause)
diet
pregnancy
How much iron is there in the body and where is it?
4g of iron in the body
much of which is in the liver and other organs
Which two substances are required to make nucleotides for cell division? Where are they obtained from?
B12 - dairy products
folic acid - leafy greens
How is serum created?
citrate and EDTA are in the blood test tube
EDTA binds to calcium
this stops clotting from happening
the supernatant of the clotted blood is serum - lacks clotting factors
What proteins are included in the blood?
Albumin
Ig
Clotting factors (fibrinogen)
What percentage of blood is made of cells?
40-45%
MCV
mean cell volume and basically tells us cell size
What substance can pregnant women be deficient in and why?
folic acid as they are producing lots of nucleotides to produce a child
Which two diseases cause malabsorption of folate?
Coeliac’s disease
Crohn’s disease
What happens in pernicious anaemia?
the autoimmune system attacks the gastroparietal cells that secrete the intrinsic factor
What happens in sickle cell anaemia?
mutation in beta globin gene to produce sickle shaped RBC
due to haemolysis from sickle Hb susceptibility
What is a root cause of anaemia and what does it involve?
haemolysis
rupture of RBC and release of Hb into plasma, shorter circulation
serum
blood that lacks clotting factors
