M1 immunology and genetics

Question 1

antigen

Answer 1

foreign molecule that binds to an antibody

Question 2

immunogen

Answer 2

antigen that produces an immune response

Question 3

phenotype

Answer 3

expression of traits Ex: A, B, AB, O

Question 4

genotype

Answer 4

actual genetic makeup Ex: A/A, A/O, B/B, O/O

Question 5

What Immunoglobulins does BB deal with?

Answer 5

IgG, IgM

Question 6

characteristics of antigens

Answer 6

on RBCs
agglutinate
located on bacteria, virus etc
made of proteins

Question 7

characteristics of antibodies

Answer 7

in plasma/serum

Question 8

IgG reacts at 37 degrees c (room temp)

Answer 8

true

Question 9

igm reacts at 22 or less degrees c

Answer 9

true

Question 10

what are the immunoglobulins

Answer 10

G, A, M, E, D

Question 11

antigen-antibody reactions

Answer 11

immune complex
in vivo
in vitro

Question 12

immune complex

Answer 12

when antigen and antibody combine

Question 13

in vivo

Answer 13

if an antibody attaches to RBC, the RBC will hemolyze due to complement being activated

Question 14

in vitro

Answer 14

agglutination should occur for positive result

Question 15

agglutination steps

Answer 15

1. sensitization
2. lattice formation

Question 16

sensitization

Answer 16

no visible agglutination occurs

Question 17

lattice formation

Answer 17

visible cross linked agglutination

Question 18

factors contributing to immunogenicity

Answer 18

degree of foreignness
size
dosage
route of administration

Question 19

explain the reagents used to determine the antigens on a patients RBC

Answer 19

anti a, anti b, anti ab

Question 20

explain the reagents used to determine the antibodies on a patients serum/plasma