Lympma and leukaemia Flashcards
Leukaemia is cancer of the blood, what four categories are used to describe it?
acute and chronic, myeloid and lymphoid.
What kind of cancerous cells are in acute and chronic leukaemias?
acute: affects early progenitor cells,
Chronic: affects more mature blood forming cells.
What kind of cells are affected in lymphoma?
affects mature lymphoid cells and mostly as lumps in the secondary lymphoid tissues.
What lymphomas aren’t found as lumps?
myelomas (terminally differentiated B cells that have returned to the bone marrow)
CLL (chronic lymphoblastic leukaemia is actually cancer of mature lymphoyctes but is found in the blood).
Can lymphomas or leukaemias cause anaemia, leukopenia (and infections) or thrombocytopaenia?
leukaemias.
What leukaemias occur early, mid and late in myeloid differentiation?
early and latest in lymphoid differentation?
AML
CML
and MDS
ALL early in lymphoid generation in BM. Lymphoblastic lymphoma (before becoming a memory B cell).
What determines Hodkin lymphoma?
Reed sterbeck cells (mostly classical) Less common but seen more typically in young people.
What two cells can non hodgkins affect?
T and B cells
T cells mostly more severe, apart from indolent skin manifestation.
B cells can be high grade and low grade.
What is high grade B cell lymphomas?
DLBCL, Burkitts and Lymphoblastic lymphoma
What are the low grade B cell lymphomas?
(CLL)
follicular
marginal zone.
Which lymphomas are slowly progressive and not curable, but treatable? Barely ever seen in children
Low grade lymphomas
Which lymphomas are rapidly progressive but curable (rituximab and ChoP). Incidence increases with age?
High grade lymphomas.
