Lymphoproliferative Disorders

Question 1

What is the normal size of a lymph nodes and above what size suggests lymphoma?

Answer 1

Normal size 0.5-1 cm; >2 cm suggests lymphoma.

Question 2

Non-Hodgkin’s lymphoma types are classified according to their cell of origin. Provide some B cell lymphomas according to whether they arise from pre-germinal center, germinal center, and post-germinal center lymphomas.

Answer 2

Pre GC: mantle cell lymphoma, CLL, SLL.
GC: Burkitt lymphoma, GCB DLBCL, Follicular lymphoma, marginal zone lymphoma.
Post GC: ABC DLBCL, multiple myeloma.

Question 3

List investigations that can detect the presence of clonality of a possible lymphoma.

Answer 3

Immunophenotyping: flow cytometry, immunohistochemistry.

Molecular studies.

Question 4

What cell marker is indicative of a pre-germinal B cell?

Answer 4

CD5.

Seen in CLL, mantle cell lymphoma.

Question 5

What cell marker is indicative of a germinal centre B cell?

Answer 5

CD10.

Seen in Burkitt, follicular lymphoma, GCB DLBCL.

Question 6

What translocation is seen in mantle cell lymphoma?

Answer 6

t(11;14)

Question 7

What translocation is seen in Burkitt lymphoma?

Answer 7

t(8;14)

Question 8

What translocation is seen in Follicular lymphoma?

Answer 8

t(14;18)

Results in Bcl2 mutation, and preventing apoptosis.