Lymphoma

Question 1

What can Hodgkin lymphoma be further classified into?

Answer 1

Classical Hodgkin lymphoma and

Nodular lymphocyte predominant Hodgkin lymphoma

Question 2

Which out of Hodgkin’s lymphoma and non-hodgkin’s lymphoma has a generally better prognosis?

Answer 2

Hodgkin

Question 3

Describe the age distribution of hodgkin lymphoma

Answer 3

bimodal- young adults and the elderly

Question 4

What is the most common subtype of classical Hodgkin lymphoma?

Answer 4

nodular sclerosis

Question 5

What are the 4 subtypes of classical hodgkin lymphoma?

Answer 5

nodular sclerosis
lymphocyte rich
lymphocyte depleted
mixed cellularity

Question 6

Which virus that causes glandular fever is Hodgkin’s lymphoma associated with ?

Answer 6

EBV

Question 7

What is the most aggressive subtype of classical Hodgkin lymphoma?

Answer 7

lymphocyte depleted

Question 8

What type of Reed-Sternberg cells might you see in nodular sclerosis ?

Answer 8

lacunar cells (small nucleus, big cytoplasm)

Question 9

What are the neoplastic cells in Hodgkin lymphoma called?

Answer 9

They can be Hodgkin cells

Or Reed-Sternberg cells- these are multinucleate

Question 10

If the lymph nodes are tender and mobile, is it likely to be Hodgkin’s?

Answer 10

no. It is likely to just be reactive lymphadenopathy due to infection

Question 11

Describe the lymph nodes in lymphoma

Answer 11

swollen, fixed and non-tender

Question 12

Describe the symptoms of classical Hodgkin’s lymphoma?

Answer 12

Painless cervical lymphadenopathy
fever, night sweats, weight loss
(in the nodular sclerosis subtype mediastinal lymphadenopathy is common)

Question 13

How is Hodgkin lymphoma diagnosed ?

Answer 13

lymph node biopsy

Question 14

How is classical Hodgkin lymphoma treated?

Answer 14

either chemotherapy alone or chemotherapy followed by radiotherapy

Question 15

What cell type is present in Hodgkin lymphoma, but not present in non Hodgkin?

Answer 15

Reed-Sternberg cells

Question 16

Give 6 types of non-Hodgkin b-cell lymphoma

Answer 16

diffuse large b-cell lymphoma 
follicular lymphoma 
Burkitt lymphoma 
Mantel cell lymphoma 
Marginal zone lymphoma 
Lymphoplasmacytic lymphoma

Question 17

Which type of non-Hodgkin b-cell lymphoma causes waxing a waning painless lymphadenopathy?

Answer 17

follicular lymphoma

Question 18

Which type of non-Hodgkin b-cell lymphoma is often associated with EBV and can have extra nodal involvement of either the jaw or at the ileocecal junction?

Answer 18

Burkitt lymphoma

Question 19

Which gene is overexpressed in follicular lymphoma?

Answer 19

BCL2

Question 20

What does the BCL2 gene normally block?

Answer 20

apoptosis

Question 21

Which mutations are associated with diffuse large b-cell lymphoma?

Answer 21

BCL2 and BCL6

Question 22

Name two types of non-Hodgkin t-cell lymphoma

Answer 22

adult t-cell lymphoma

mycosis fungoides

Question 23

Which type of lymphoma is caused by human t-lymphotropic virus?

Answer 23

adult t-cell lymphoma

Question 24

How is non-Hodgkin lymphoma treated?

Answer 24

chemotherapy and radiotherapy

Question 25

What is the difference between Hodgkin and non-Hodgkin lymphoma in terms of the pattern of spread ?

Answer 25

Hodgkin- spreads contiguously

Non-Hodgkin- spreads non-contiguously

Question 26

Which out of Hodgkin and non-Hodgkin lymphoma rarely involves extranodal sites ?

Answer 26

Hodgkin