Lymphoma

Question 1

Ann arbor staging classification..what is at

Answer 1

anatomic staging system that parallels with non hodgkin lymphoma and hodgkin dz

Question 2

Ann arbor stage 1

Answer 2

single lymph node or single lymphatic origin

Question 3

Ann arbor stage 2

Answer 3

2 or more lymph node regions or extra lymphatic sites on same site of diaphragm

Question 4

Ann arbor stage 3

Answer 4

involvement of lymph node regions or extra lymphatic sites on both sides of diaphragm

Question 5

Ann arbor stage 4

Answer 5

diffuse or disseminated involvement of more than one extra lymphatic organ w/wo lymph node involvement,

Bone marrow involvement confers stage 4 designation

Question 6

Cotswold modifications of ann arbor

Answer 6

• Bulky dz: 33% or more of internal transverse thoracic diameter
• Number of anatomic regions involved should be indicated by subscript
• Stage 3 may be subdivided into- III(1): w/wo splenic, hilar, celiac, or portal nodes, III(2): with paraortic, iliac, or mesenteric nodes
• staging should be identified as clinical or pathological stage
• category of response to therapy
• new category: unconfirmed/uncertain complete remission

Question 7

What are non-Hodgkin lymphomas

Answer 7

lymphocytic cancers predominately of be cell origin, with NO reed Sternberg cells

Question 8

Non hodgkins lymphoma incidence

Answer 8

• median age 66
• more common in men
• highest incidence in US
• increased chance with Epstein-barr, HTLV 1, hepatitis C, H pylori
• associated with warm-antibiody autoimmune, hemolytic anemias
• anticipate superior vena cava dz, cardiac tamponade

Question 9

S&S of non-Hodgkin’s lymphoma

Answer 9

Lymphadenopathy-painless, widespread, or isolated
mostly asymptomatic
Fever
Night sweats
Weight loss
Abdominal fullness- most common in BURKITT lymphoma
Skin ulcers
Splenomegaly
Hepatomegaly