Lymphoma

Question 1

What 4 major factors must a doctor look at when deciding if a cure is possible in alymphoma patient?

Answer 1

Tumor histology, stage, condition of patient, available therapies

Question 2

Name the most common indolent lymphoma?

Answer 2

Follicular Center Cell Lymphoma (B cell)

Mycosis Fungoides ) T Cell

Question 3

Most common aggressive Lymphoma?

Answer 3

Diffuse Large Cell

Question 4

Highly aggressive?

Answer 4

Burkitts (t(8;14)

Question 5

Stage 1

Answer 5

Single node or lymphoid structure

Question 6

Stage 2

Answer 6

two or more nodes on one side of diaphragm

Question 7

Stage 3

Answer 7

Both sides of diapraghm

Question 8

Stage 4

Answer 8

Extranodal

Question 9

Major treatment differences between indolent and aggressive

Answer 9

Indolent- usually higher stage, only curable at stage I and II. Slower progression, simple therapy survival doesnt depend on early treatment
Aggressive- Often lower stage but it moves rapidly, complex therapy, early therapy required. Potential cure

Question 10

Therapy of indolent lymphoma

Answer 10

local irradiation, alkylators and prednisone,
Fludarabine- purine analog
Anibody therapy- Rituximab
Combo chemotherapy- CHOP

Question 11

Therapy of aggressive lymphoma

Answer 11

CHOP, antibody therapy plus CHOP, radio-immunotherapy, short course chemo, Bone marrow transplant

Question 12

How does Rituximab work?

Answer 12

Rituximab attaches to CD 20 on B cells and draws in complement to kill the tumor.

Question 13

See rituximab think what?

Answer 13

CD 20…B cell death

Question 14

Imrutinib?

Answer 14

Promotes apoptosis. BtK inhibitor

Question 15

Most common cutaneous lymphoma?

Answer 15

Mycosis Fungoides

Question 16

Mycosis Fungoides is associated with what kinds of cells?

Answer 16

Sezary cells, Reed Sternberg CellsH

Question 17

Hodgkins Lymphoma treatment?

Answer 17

ABVD

Question 18

Complications of radiation therapy in young Hodgkins women

Answer 18

Infertility

Question 19

Two complications of CLL?

Answer 19

recurrent infections

Question 20

Poor prognostic markers in CLL?

Answer 20

del 17p. (p53), Zap 70, CD 38

Question 21

In follicular B cell lymphoma, what is the translocation?

Answer 21

t(14;18) IgH-BCL2

Question 22

What is the major immunophenotype marker tested for in Follicular B cell lymphoma?

Answer 22

BCL2

Question 23

What can folicular B cell lymphoma turn into?

Answer 23

Diffuse Large B cell lymphoma

Question 24

Describe the grading of follicular lymphoma

Answer 24

Grade 1- mostly centrocytes, Grade 2- centrocytes and centroblasts, grade 3- centroblasts

Question 25

How is diffuse large B cell Lymphoma different from follicular lymphoma?

Answer 25

Rapidly dividing and extranodal involvement.

Question 26

Treatment of Diffuse large B cell Lymphoma

Answer 26

CHOP (cyclophosphamide, doxyrubicin hydrochloride, vincristine, prednisone

Question 27

Four types of Hodgkins Lymphoma (coons)

Answer 27

Nodular lymphocyte predominant (best)
Nodular sclerosing (women> men)
Mixed Cellularity (EBV)
Leukocyte Depleted (worst)