Lymphoma Flashcards
What 4 major factors must a doctor look at when deciding if a cure is possible in alymphoma patient?
Tumor histology, stage, condition of patient, available therapies
Name the most common indolent lymphoma?
Follicular Center Cell Lymphoma (B cell)
Mycosis Fungoides ) T Cell
Most common aggressive Lymphoma?
Diffuse Large Cell
Highly aggressive?
Burkitts (t(8;14)
Stage 1
Single node or lymphoid structure
Stage 2
two or more nodes on one side of diaphragm
Stage 3
Both sides of diapraghm
Stage 4
Extranodal
Major treatment differences between indolent and aggressive
Indolent- usually higher stage, only curable at stage I and II. Slower progression, simple therapy survival doesnt depend on early treatment
Aggressive- Often lower stage but it moves rapidly, complex therapy, early therapy required. Potential cure
Therapy of indolent lymphoma
local irradiation, alkylators and prednisone,
Fludarabine- purine analog
Anibody therapy- Rituximab
Combo chemotherapy- CHOP
Therapy of aggressive lymphoma
CHOP, antibody therapy plus CHOP, radio-immunotherapy, short course chemo, Bone marrow transplant
How does Rituximab work?
Rituximab attaches to CD 20 on B cells and draws in complement to kill the tumor.
See rituximab think what?
CD 20…B cell death
Imrutinib?
Promotes apoptosis. BtK inhibitor
Most common cutaneous lymphoma?
Mycosis Fungoides
Mycosis Fungoides is associated with what kinds of cells?
Sezary cells, Reed Sternberg CellsH
Hodgkins Lymphoma treatment?
ABVD
Complications of radiation therapy in young Hodgkins women
Infertility
Two complications of CLL?
recurrent infections
Poor prognostic markers in CLL?
del 17p. (p53), Zap 70, CD 38
In follicular B cell lymphoma, what is the translocation?
t(14;18) IgH-BCL2
What is the major immunophenotype marker tested for in Follicular B cell lymphoma?
BCL2
What can folicular B cell lymphoma turn into?
Diffuse Large B cell lymphoma
Describe the grading of follicular lymphoma
Grade 1- mostly centrocytes, Grade 2- centrocytes and centroblasts, grade 3- centroblasts
How is diffuse large B cell Lymphoma different from follicular lymphoma?
Rapidly dividing and extranodal involvement.
Treatment of Diffuse large B cell Lymphoma
CHOP (cyclophosphamide, doxyrubicin hydrochloride, vincristine, prednisone
Four types of Hodgkins Lymphoma (coons)
Nodular lymphocyte predominant (best) Nodular sclerosing (women> men) Mixed Cellularity (EBV) Leukocyte Depleted (worst)