lymphoma

Question 1

what is a lymphoma?

two main subtypes

Answer 1

neoplastic transformation of B and T cells residing in lymphoid tissue
Hodgkin and non Hodgkin lymphoma

Question 2

what is its classification based on

Answer 2

histological findings

reed Sternberg cell presence

Question 3

differences between the two

Answer 3

Hodgkins - rare, less than 1500 cases in the uk annually
seen in young adults 20-35 years of age and again at 50-60 years of age
associated with EBV
often increased risk if first degree relative has it
obesity
males

non-Hodgkin lymphoma
13,000 cases annually in the UK (10x more common than HL). 
70% are B cells 
more common in over 40s 
30% have an extranodal disease (outside lymphatic system) 
can occur in immunocompromised HIV, Herpes simplex
working in rubber exposure 
h.pylori
•Azathioprine
•Cyclosporine
previous chemo
males

Question 4

signs and symptoms

Answer 4

HL - painful cervical lymphadenopathy, weight loss, night sweats, fever, HEPATOSPLENOMAGLY, pleural effusion, fatigue, anorexia, itching

NHL : cervical lymphadenopathy, bleeding, anaemia, skin involvement is common

Question 5

what can also be seen NHL?

Answer 5

oropharyngeal lymphoid tissue waldeyers ring
sore throat
obstructed breathing
pancytopenia

Question 6

diagnosis?

Answer 6

bloods - elevated ESR, wcc, ldh can predict prognosis
LN biopsy
CT/PET for staging
reed Sternberg cells on histology

Question 7

what are the treatment options for HL

Answer 7

chemotherapy
A B V D - adriamycin, bleomycin, vinblastine, dacarbazine

irridation

PET/CET to check disease activity

Question 8

what are the treatment options for NHL

Answer 8

chemotherapy immunotherapy and irridation
CHOP 
cyclophosphamide 
hydroxyadriamycin 
oncovin
prednisolone 
irridation 

60-70% will be cured with this

Question 9

what are B symptms

Answer 9

sweating
weight loss
fatigue
fever

Question 10

which is associated with painful lymph nodes on drinking

Answer 10

Hodgkin lymphoma