Lymphoma Flashcards
Characterized by reed sternberg or owl eye cells
Hodgkins Lymphoma
Chemotherapy regimen for Hodgkins
ABVD
Adriamycin Bleomycin Vincristine Dacarbazine
Common side effect of bleomycin
Pulmonary toxicity
What infectious agent predisposes to Gastric MALT lymphoma?
H pylori
What infectious agent predisposes to multicentric Castlemans disease / primary effusion lymphoma?
Human herpesvirus 8 (HHV-8)
What infectious agent predisposes to lymphoplasmacytic lymphoma?
Hepatitis C
What infectious agent predisposes to Diffuse large B cell lymphoma and Burkitts or any Hodgkins Lymphoma?
HIV
What infectious agent predisposes to adult T cell leukemia/lymphoma?
HTLV-1
What infectious agent predisposes to Hodkins Lymphoma
EBV
Cytogenetic translocation in Mantle cell lymphoma
t(11;14)
Cytogenetic translocation in follicular lymphoma
t(14;18)
Cytogenetic translocation in anaplastic lymphoma
t(2;5)
Cytogenetic translocation in burkitts lymphoma
t(8;14)
Smudge or basket cells
B cell CLL / small lymphocytic lymphoma
CD5 Positive lymphomas are:
Mantle cell lymphoma
B cell CLL
Lymphoplasmacytic lymphoma
Most common treatment of B cell CLL
Chlorambucil or Fludarabine / Bendamustine
CD5 Negative lymphomas
MALT lymphoma
Treatment of MALT?
Single agent chlorambucil
Eradication of H pylori
Most common presentation of mantle cell lymphoma
Palpable lymphadenopathy
Lymphomatosis polyposis in the large intestines with Waldeyer ring involvement
Treatment of Mantle cell lymphoma?
HyperC-VAD
R-HyperC-VAD
Rituximab + Cyclophosphamide Vincristine Doxorubicin Dexamethasone Cytarabine Methotrexate
Double hit lymphomas MYC and BCL6
Diffuse B cell lymphoma
Starry sky appearance
Burkitts lymphoma
The most rapidly progressing tumor that always needs CSF examination to rule out mets
Burkitts lymphoma
When should treatment for burkitts start?
Treatment for both children and adults should be started within 48 hours of diagnosis
High dose cyclophosphamide
Hairy cell leukemia have monocytopenia and are prone to infections to
Mycobacterium avium intracellulare
Indolent mature T cell lymphoma with eczematous skin lesions
Mycosis fungoides
Sezary syndrome
Mycosis fungoides or cutaneous T cell lymphoma
Tropical spastic paraparesis is a presentation of what lymphoma
Adult T cell lymphoma
Flower cells
Adult T cell lymphoma HTLV 1
Has best survival rate among any aggressive lymphoma
Anaplastic large T cell lymphoma
Treatment of anaplastic T cell lymphoma?
Same as any aggressive lymphoma but rituximab is omitted
Pattern of fever in Hodgkins lymphoma
Pel Ebstein fever
Popular chemotherapy regimen for Hodgkins
ABVD
Doxo Bleo Vincristine Dacarbazine
Electric shock sensation into the lower extremities upon flexion of the neck in patients receiving thoracic radiotherapy
Lhermitte’s syndrome
Lymphoma-like disorder presenting as bulky lymphadenopathy which is non progressive and self limiting
Rosai Dorfman syndrome
