Lymphoma Flashcards
Burkitt’s immunophenotype and cytogenetics
surface immunoglobulin +
TdT negative
CD 19, 20, 22 +
Most CD 10+
Cytogenetics:
(8;14)
(8;22)
(2;8)
Lymphoblastic lymphoma immunobiology
B cell: Tdt positive, CD19, CD79a, or CD22 positive. HLA-DR +
T-cell: cytoplasmic or membrane CD3, TdT+, HLA-DR and CD34 negative
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What are the risk factors for hodgkins lymphoma?
Family Hx
EBV infection
SES- for those with HL <10yrs associated with low SES and crowding, but in young adults associated with high SES and fewer exposures to children
social contacts
what are the types of classic HL?
Nodular sclerosing
mixed cellularity
lymphocyte rich
lymphocyte depleted
what is the immunophenotype of classic HL
CD30+ CD15+ (70%) CD45 neg CD20+ (20-30%) Pax5+
what is the immunophenotype of NLPHL?
CD30 neg CD15 neg CD45+ CD20+ CD79a + Pax5 +
what is the definition of constitutional symptoms?
more than 10% weight loss in the last 6mths
drenching night sweats
fever >38C for more than 3 days and unexplained
what factors are associated with more of an adverse outcome in HL?
advanced stage
B symptoms
bulk disease
poor response to therapy
what does brentuximab target?
CD30
what cancer can transform in patients with NLPHL?
DLBCL
describe the lugano criteria
1-no uptake above background
2-uptake mediatstinum but liver
5-uptake markedly >liver and or new lesions
1 and 2= CR
3-context dependent
4 and 5= active disease
what is the ddx for mediastinal mass?
normal thymus
infection-EBV, atypical mycobacterium, histoplasmosis, toxoplasmosis
lymphoproliferative disease
malignant- HL, Lymphoblastic lymphoma, DLBCL, ALCL, primary mediastinal Bcell lymphoma, germ cell tumour, soft tissue sarcoma, lymph node met from other sites
what translocation is associated with ALCL?
t(2;5)
NPM-ALK
what translocations are associated with Burkitts lymphoma
8;14-most common
2;8
8;22
what is the immunophenotype of DLBCL?
sIg+, light chain restricted CD19, CD20, CD22, CD79a, PAX-5 + Can be CD30+ 2/3 express BCL-6 1/3 express cMYC
