Lymphoma

Question 1

How is lymphoma classifed? how is this determined

Answer 1

20% hodgkins and 80% non-hodgkins

-hodgkins lymphomas contain reed-sternberg cells

Question 2

What is a reed-sternberg cell?

Answer 2

giant malignant cells seen on light microscopy ‘owl like’

-B cell that has acquired many mutations and is responsible for the malignancy

Question 3

what are the clinical features of lymphoma?

Answer 3

B symptoms: fever, drenching night sweats, weight loss

itch without rash

alcohol induced pain (hodgkins)

Fatigue

lump

lymphadenopathy

Question 4

How is lymphoma diagnosed?

Answer 4

lymph node biopsy (usually core FNA isn’t enough and surgeon has to biopsy large area)

Question 5

What 5 different pathological investigations are done for lymphomas?

Answer 5

Histology: microscopic appearances

Immunohistochemistry on the solid node: confirms a lymphoma and helps to sub classify

immunophenotyping on blood/marrow: determines pattern of CD number using abody fluorescence

Genetic analysis: FISH

Molecular analysis: patterns of gene expression

Question 6

which are the 4 different types of hodgkins lymphoma?

Answer 6

Nodular sclerosing
Mixed cellularity
Lymphocyte predominant
Lymphocyte depleted

Question 7

what is the prognosis for
Nodular sclerosing
Mixed cellularity
Lymphocyte predominant
Lymphocyte depleted
hodgkins lymphoma

Answer 7

NS: good
MC: good
LP:best
LD: worst

Question 8

What is the frequency of
Nodular sclerosing
Mixed cellularity
Lymphocyte predominant
Lymphocyte depleted

Answer 8

NS: most common 70%
MC: around 20%
LP: 5%
LD: rare

Question 9

Nodular sclerosing hodgkins lymphoma:

• more common in women or men?
• what cells are assoc.?

Answer 9

more common in women

assoc. with lacunar cells

Question 10

Mixed cellularity hodgkins lymphoma:

-what cells are assoc.

Answer 10

Large number of reed-sternberg cells