Lymphoma Flashcards
1
Q
Which NHL have CD5+?
A
- CLL/SLL
- Mantle cell
- DLBCL (rare)
2
Q
What is the characteristic cytogenetic abnormality in Follicular lymphoma?
A
t(14;18)
BCL2
3
Q
What is the characteristic cytogenetic abnormality in Mantle cell lymphoma?
A
t(11;14)
Cyclin D1
4
Q
What is the characteristic cytogenetic abnormality in Waldenstrom’s?
A
MYD88
5
Q
What is the characteristic cytogenetic abnormality in Burkitt’s?
A
t(8;14)
cMYC
6
Q
What are components of IPI score? (APLES)
A
- Age > 60
- PS > 2
- LDH elevated
- Extranodal sites > 1
- Stage III or IV
7
Q
What marker may help differentiate PMBCL?
A
CD30
8
Q
What are components of FLIPI score? (NOLASH)
A
- NOdal sites of disease > 4
- LDH elevated
- Age > 60
- Stage III or IV
- Hemoglobin < 5
