Lymphoma

Question 1

What are the two main types of lymphoma?

Answer 1

Hodgkin’s and Non hodgkin’s

Question 2

Is lymphoma more common in males or females?

Answer 2

Males

Question 3

What are the risk factors for Hodgkin’s lymphoma?

Answer 3

Age - over 50s (two peaks, early 20s, over 55s)
Family history
Being male
EBV infection status
Immunosuppression

Question 4

Which cells are necessary for a diagnosis of Hodgkin’s lymphoma?

Answer 4

Reed-Sternberg Cells

Question 5

Which cell types can be found in Hodgkin’s lymphoma?

Answer 5

Reed-Sternberg cells
Lacuna cells
Popcorn cells

Question 6

Has the incidence of Hodgkin’s lymphoma been increasing or decreasing since the 1970s?

Answer 6

Decreasing.

Question 7

What was the incidence of Hodgkin’s lymphoma in 2010?

Answer 7

1866 (1072 males, 794 females)

Question 8

Have mortality rates of Hodgkin’s lymphoma been increasing or decreasing since the 1970s?

Answer 8

Decreasing.

Question 9

Name 5 different types of Non-Hodgkin’s lymphoma.

Answer 9

Burkitt's lymphoma
Mantle Cell Lymphoma
Follicular Lymphoma
Marginal zone lymphoma
DLBCL

Question 10

Have incidence rates of Non-Hodgkin’s lymphoma been increasing or decreasing since the 1970s?

Answer 10

Increasing.

Question 11

What is the survival rate of Non-Hodgkin’s lymphoma?

Answer 11

60-65% 5 year survival

Question 12

What is the most treatable type of non-Hodgkin’s lymphoma?

Answer 12

Follicular lymphoma

Question 13

What is the least treatable type of non-Hodgkin’s lymphoma?

Answer 13

Mantle cell lymphoma.

Question 14

Which Ig type is mostly involved in the primary immune response?

Answer 14

IgM

Question 15

Which Ig type is mostly involved in the secondary immune response?

Answer 15

IgG

Question 16

Which different zones are found in the germinal centre?

Answer 16

Dark zone - full of centroblasts
Light zone - full of centrocytes (and follicular dendritic cells)
Mantle zone - containing resting memory B cells
Marginal zone - containing many different cell types

Question 17

Which cells are Ag bound to in the germinal centre?

Answer 17

Follicular dendritic cells.