lymphoid tissue

Question 1

what is meant by the progenitor stage

Answer 1

when the cell can differentiate into a specific cell type

Question 2

what is a primary lymphoid organ and name some examples ?

Answer 2

• where lymphocytes are produced (lymphopoieses)
• Thymus, Bone marrow, Foetal liver

Question 3

What are the key characteristics of the adaptive immune response ?

Answer 3

1. specificity ( provided by the vast range of unique T and B cell receptors)
2. Memory ( the rapid expansion in response to secondary encounter)

Question 4

Both of the B + T cell receptors are…..

Answer 4

heterodimer

Question 5

what process do T and B cells use to produce a large repertoire of receptors

Answer 5

VDJ recombination

Question 6

Describe the differences and similarities between the TCR and the BCR?

Answer 6

similarities:
- both heterodimers (composed of 2 chains)
- both have antigen binding sites
differences:
- TCR are made up of an alpha and a beta chain whilst BCR are made up of a heavy and light chain.
- TCR only has one antigen binding site but BCR has 2

Question 7

What is the primary site of haematopoiesis

Answer 7

bone marrow

Question 8

Through which specialised vessels do naïve lymphocytes leave the circulation and migrate into secondary lymphoid tissue?

Answer 8

High endothelial venules (HEVs)

Question 9

What is a germinal centre?

Answer 9

anatomically restricted area where B cells undergo mutation and selection to generate high affinity antibodies