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Lymph histology lab > Lymphoid System Histology > Flashcards

Lymphoid System Histology Flashcards

1
Q

Antigen-Presenting Cells (APCs)

A
  • APCs survey the body, recognize and phagocytose Ags
  • Peptide fragments of Ags bind to MHC molecules and are displayed on cell surface.
  • Class I MHC – expressed by all nucleated cells
  • Class II MHC–expressed mainly by APCs
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2
Q

T cells – cellular immune responses

A

Detect cell bound Ags presented by MHC molecules:

  • T helper cells- CD4+, helper functions via contacts with APCs and other lymphocytes
  • T cytotoxic cells – CD8+, cytotoxic functions–recognition & lysis of virally infected cells
  • T regulatory cells – CD4+, FoxP3, limit the immune response, produce inhibitory cytokines
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3
Q

B cells- humoral immune responses

A
  • Detect soluble (unlike T cells!) or cell- bound Ags
  • B cells differentiate into antibody-secreting plasma cells
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4
Q

Lymphoid Tissue

A
  • Lymphocytes
  • Supporting cells

–Macrophages

–Dendritic cells

–Granulocytes

–Reticulocytes (Except thymus!)

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5
Q

What is depicted in the image

A

Stroma: the framework of cells subdivide parenchyma into ‘subdivisions’ & support parenchymal cells

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6
Q

What is depicted in the image

A

Parenchyma: Lymphoid cells

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7
Q

What is depicted in the image

A

Diffuse Lymphoid Tissue

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8
Q

What is depicted in the image

A
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9
Q

What is depicted in the image

A

Lymphoid nodules B cell area

•Primary & secondary follicles

–B cells

–Follicular dendritic cells(mesenchymal origin, NOT bone marrow-derived!)

  • Primary follicle- naïve recirculating B cells
  • Secondary follicle contains germinal center established by

activated B cells.

–Germinal center B cells undergo somatic hypermutations

–B cells with mutations that improve affinity for Ag are selected and exit a germinal​ center

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10
Q

Central (Primary) Lymphoid Organs

A
  • Bone Marrow
  • Thymus
  • Fetal liver
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11
Q

Peripheral (Secondary) Lymphoid Organs

A
  • Lymph nodes
  • Spleen
  • MALT

Tonsils

Peyer’s patches

 Appendix

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12
Q

what is depicted by the image

A

Bone marrow

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13
Q

what is depicted by the image

A

Thymus

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14
Q

Secondary lymphoid organs:

A

•Facilitate the induction of adaptive immune responses

–Capture pathogens

–Facilitate encounters between APCs & lymphocytes

–Provide niches for the differentiation of immune effector cells

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15
Q

what is depicted in the image

A

MALT

  • T cells (CD8 + intraepithelial, CD8 + & CD4 + lymphocytes in lamina propria)
  • IgA- secreting plasma cells (after forming in germinal centers remain in the MALT)
  • Granulocytes (Neutrophils are RARE in the healthy MALT)
  • APCs
  • M cells in Peyer’s patches and tonsils
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16
Q

What is depicted in the image

A

BALT

(bronchus-associated lymphoid tissue)

17
Q

Lingual

A

stratified squamous, single crypt. On the base of a tongue (distal one third).

18
Q

Pharyngeal (Adenoids)

A

pseudostratified ciliated columnar with some stratified squamous; no crypts but shallow pleats. In the posterior wall of nasopharynx

19
Q

Palatine

A

covered with stratified squamous non- keratinizing epithelium. In the palatine fossa

  • Many (10-12) deep crypts
  • Capsule underneath
  • Skeletal muscle deep to capsule
20
Q

What is depicted in the image

A

Palatine Tonsil

21
Q

What is depicted in the image

A
22
Q

Peyer’s Patches Microfold (M) cells

A

M cells:

  • Have a folded luminal surface
  • Do not have a brush border
  • Are not covered by glycocalyx
23
Q

What is depicted in the image

A

Peyer’s Patches Microfold (M) cells

24
Q

Appendix

A

lack of villi, lymphoid tissue in lamina propria and submucosa

25
Q

What is depicted in the image

A

Appendix

26
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What is depicted in the image

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27
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What is depicted in the image

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28
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What is depicted in the image

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29
Q

What is depicted in the image

A

Metastatic cancer cells can enter lymphatics and invade the nearby (sentinel) lymph node. Cancer cells, often immunosuppressive continue to grow within the lymph node.

30
Q

What is depicted in the image

A

Cortex and Medulla

31
Q

What is depicted in the image

A
32
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What is depicted in the image

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33
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What is depicted in the image

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34
Q

What is depicted in the image

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Lymph histology lab (2 decks)

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