lymphoid structures Flashcards
primary immune organs
bone marrow - immune cell production, B cell maturation
Thymus- T cell maturation
secondary immune organs
spleen, lymph nodes, tonsils, Peters patches
allows immune cells to interact with antigen
lymph node
a secondary lymphoid organ that has many afferents, 1 or more efferents.
lymph node is encapsulated with ____
trabecular
function of lymph nodes
nonspecific filtration by macrophages, circulation of B and T cells, and immune response activation
lymph node is made of 3 parts
follicle, medulla, paracortex,
follicle
site of b cell localization and proliferation, in outer cortex. primary follicles are dense and quiescent. secondary foibles hav pale central centers and are active
medulla
consists of medullary cords (closely packed lymphocytes and plasma cells) and medullary sinuses. Medullary sinuses communicate with efferent lymphatic and contain reticular cells and macrophages
paracortex
contains T cells
region of cortex between follicle and medulla. contains high endothelial venules through which T and B cells enter from blood. Not well developed in patients with digeorge syndrome.
paracortex ____ in an extra cellular immune response
enlarges (ex EBV ad other viral infections -> paracortical hyperplasia -> lyphadenopathy)